fungal, neoplastic, misc diseases of mice and rats
Terms
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- fungal diseases
-
mice and rats:
trichopyton mentagrophytes
pneumocystis carinii - neoplastic diseases
-
mice:
mammary tumors
lymphosarcoma
respiratory neoplasms
rats:
mammary fibroadenoma
pituitary chromphone adenoma - miscellaneous dz
-
rats:
malocclusion
heat exhaustion
urolithiasis
ringtail
rat bite fever
mice:
alopeicia
fight wounds
self mutilation (otitis media, acariasis, chem irritants)
infertility
dystrophic mineralization
ulcerative dermatitis - et of trichophyton mentagrophytes for mice and rats
- fungus aka favus
- trans of trichophyton mentagrophytes for mice and rats
-
direct contact
fomites
wide host range - clin signs of trichophyton mentagrophytes for both mice and rats
-
none
head alopenia and focal crusts - histopath and gross path of trichophyton mentagrophytes
-
histo - silver stain (mice don't have hair invasion)
gross - clin signs - Dx of trichophyton mentagrophytes
-
culture
lesions - Tx and ctrol of trichophyton mentagrophytes
-
tx: none
ctrol: sanitaion / good hygien
zoonotic - et agent of pneumocystic carinii
-
fungus
affects immunocompromised rodents - trans of pneumocystic carinii
- direct contact
- clin signs of pneumocystsi carinii
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both:
srs
clin signs occur late - gross path of pneumocystis carinii
-
both:
diffusely red
lungs fail to deflate - histopath of pneumocystic carinii
-
both:
alveoli
eosinophilic, foamy
degenerate macs and neutr
special stains
silver stain
pas
giemsa - Dx and treatment of pneumocystic carinii
-
Dx both:
histopath
pcr
ctrol both:
management and sanitaion - transmission of mouse mammary tumors
-
vertically (placental / milk)
strain dependent - clin signs of mouse mammary tumors
- located anywhere sq
- gross path of mouse mammary tumors
- soft, flexhy, well vascularized
- Dx of mouse mammary tumors
-
location
histopath - et of lymphosarcoma (mouse)
- murine leukemia virus (retrovirus)
- et of respiratory neoplasms
-
common in older mice
strain dependent
not virally associated - gross path of respiratory neoplasms (mouse)
- firm, cirucumscriped pearl to gray nodules
- most common rat tumor
- mammary fibroadenoma
- presentation of mammary fibroadenoma
-
(rats)
large sw lump
ulceration
dematitis
well encapsulated / benight
tx with surgery - common tumor in older rats
- pituitary chroophobe adenoma
- clin signs of pituitary chromophobe adenoma
-
srs
chromodaccorrhea
head tilt - gross path of pituitary chromophobe adenoma
-
well circumscribed
dark brown to red
compress adjacent brain
pars distalis - et of malocclusion
-
rats an dmice:
improbper alignemet of maxillary and mandibular incisorys - clinical signs of heat exhaustion in rats
-
salivation - wet hair coat
increased water consumption
death - risk factors for chronic progressive glomerulonephropathy in rats
-
age greater than 1 yr
male
sd strain
high protein diet
Igm deposits
prolactin hormones - clin signs of chronic progressive glomerulocephropathy
-
proteinurea
wt loss
elevated plasma creatinine - gross path of chronic progressive glomerulonephropathy
- pale pitted, irregular, enlarged kidneys
- histopath of chronic progressive glomerulonephropathy
-
basement membrane and glomerular tuft thickening
proteinaceous tubular casts
hyperparathyroidism - et of ringtail
- high temp and low humidity
- et of rat bite fever
-
rats - strep moniliformis
mice - spirilium muris
zoonotic