Leishmania
Terms
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- heteroxenous life cycle
- life cycle in more than 1 host-invert/vert
- What are the stages in the life cycle of a leishmania?
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1. Amastigote-when in vertebrate tissues
2. Promastigote-when in gut of fly - infected
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internal
ex. trypanosome - infested
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external
ex. fly larvae - suprapylaria
- midgut before moving anterior
- peripylaria
- develop in hindgut
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L. Tropica
L. Major -
tropical diseases that cause oriental sores.
cutaneous leishmaniasis - lesion
- abnormal pathology
- L. donovani
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causes Kala-Azar or Dum Dum Fever, distributed in Africa and India
Pathogenisis and Chronic Disease - pathogenesis
- onset of causing disease
- What is the life cycle of L. donovani?
- The infected fly bites the human, parasites are engulfed by macrophages (out of vascular) which are killed by parasite. The cycle continues where macrophages burst and infect others till the reticuloendothelial (moncyte & macrophage) system is severly damaged. Human suffers annemia and death
- Dermal leishmanoid
- develops in 5-10% of infected humans in India. It causes disfiguring
- L. Braziliensis
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S. America, causes the disease called espundia (mucocutaneous leishmaniasis)
causes ulcers