NSAIDS
Terms
undefined, object
copy deck
- Name 8 other side-effects are associated with acetyl-salicylate?
-
1) Anorexia
2) Vomiting
3) Hemorrhage
4) GI ulceration
5) Nephrotoxicity
6) Hepatotoxicity
7) Blood dyserasia
8) Hypersensitivity - Name 10 drugs that are classified as NSAIDS.
-
1) Acetyl-salicylate (aspirin)
2) Acetominophen
3) Phenylbutazone
4) Carprofen
5) Flunixin (banamine)
6) Ketoprofen
7) Naproxen (alleve)
8) Piroxicam
9) Carbolic Acids (etodolac)
10) Miloxicam - What is the mechanism for acetominophen?
- centrally active
- What are the 2 secondary effects of NSAIDS, in general?
-
1) Antithrombotic: bind COX-1 in platelets, inhibiting TXA2 and clotting
2) Renal vasodilation by closing of efferent arterioles/opening of afferents - What is the indication for acetominophen?
- pain relief ONLY
- What 2 AMDE aspects that are related to NSAIDS, in general?
-
1) HUGE variation in T1/2 of elimination among species and among individuals within species
2) HIGHLY PROTEIN BOUND (phase I and II) - What are the 7 contraindications associated with acetyl-salicylate?
-
1) Gastric ulcers (w/ glucocorticoids)
2) Anticoagulants (compete for protein binding sites)
3) Renal/hepatic disease
4) Late pregnancy
5) GI ulcers
6) Dehydration
7) Inhibit excretion (w/ Digoxin) - What are the 4 primary effects that NSAIDS produce, in general?
-
1) Decrease eicosanoids (thromboxane, prostacycline, prostaglandins)
2) Inhibit pain centrally
3) Decrease peripheral "pain threshold"
4) Decrease fever (decrease PGE) - What is the primary effect of acetominophen?
- inhibits pain centrally
- What are the 2 mechanisms used by acetyl-salicylate?
-
1) Acetylates irreversibly bind COX-1
2) Affect opiate receptors (CNS)
- Name 8 other effects of NSAIDS, in general.
-
1) Anorexia
2) Vomiting
3) Hemorrhage
4) GI ulceration
5) Nephrotoxicity
6) Hepatotoxicity
7) Blood dyserasia
8) Hypersensitivity - Name 7 contraindications for NSAIDS, in general.
-
1) Gastric ulcers (w/ glucocorticoids)
2) Anticoagulants (compete for protein binding sites)
3) Renal/hepatic disease
4) Late pregnancy
5) GI ulcers
6) Dehydration
7) Inhibit excretion (w/ Digoxin) - What are the 4 indications of NSAIDS, in general?
-
1) Reduce inflammation (eg arthritis, fever)
2)Reduce pain (eg colic)
3)Prevent pain (eg perioperative)
4) Prevent endotoxic shock - What are 3 indications for acetyl-salicylate?
-
1) Reduce inflammation
2) Reduce pain
3) Inhibit clotting - What are the 4 primary effects of acetyl-salicylate?
-
1) Decrease eicosanoids (thromboxane, prostacycline, prostaglandins)
2) Inhibit pain centrally
3) Decrease peripheral "pain threshold"
4) Decrease fever (decrease PGE) - What is the relationship of COX-1 and -2 with regards to NSAIDS, in general?
- COX-2:COX-1 should be <1
- What are the 3 mechanisms used by NSAIDS, in general?
-
1) Inhibit cyclo-oxygenase I or II
2) Affect opiate receptors (CNS)
3) Variations on these themes - Name the AMDE associated with acetyl-salicylate.
- Very long T1/2 in CAT
- What are the 2 secondary effects of acetyl-salicylate?
-
1) Antithrombotic: bind COX-1 in platelets, inhibiting TXA2 and clotting
2) Renal vasodilation by closing of efferent arterioles/opening of afferents