usmle-manual
Terms
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- Autosomal Dominant Diseases
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382. Adult Poly Cystic Kidney Disease
383. Familial Hypercholestrolemia Disease
384. Hereditary Hemorrhagic Telengectasia (Osler-Weber-Rendu)
385. Hereditary Spherocytosis
386. HuntingtonÂ’s Disease (chromosome 4p)
387. MarfanÂ’s Syndrome
388. Neurofibromatosis (von RecklinghausenÂ’s)
389. Tuberous Sclerosis
390. Von Hippel Lindau Disease -
Autosomal Recessive
Diseases -
391. Tay-Sachs
392. GaucherÂ’s
393. Niemann-Pick
394. HurlerÂ’s
395. Von GierkeÂ’s
396. PompeÂ’s
397. CoriÂ’s
398. McArdleÂ’s
399. Galactosemia
400. PKU
401. Alcaptonuria
--- Cystic fibrosis - X Linked Recessive Diseases
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402. HunterÂ’s Syndrome (L-Iduronosulfate Sulfatase deficincy, inc Heparan/Dermatan Sulfate)
403. Fabry’s Disease (ƒ¿ Galactosidase A deficiency, inc Ceremide Trihexoside)
404. Classic Hemophilia A (Factor VIII deficiency, F8 Gene on X chromosome is bad, inc Ceremide Trihexoside)
405. Lisch-Nyhan Syndrome (HGPRT deficiency, inc Uric acid)
406. G6Phosphatase deficiency (G6PDH deficiency, inc Ceremide trihexoside)
407. DuchenneÂ’s Muscular Dystrophy (Dystrophin deficinecy, inc Ceremide Trihexoside) - Lung Development
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Glandular: 5-17 fetal weeks
Canalicular 13-25 fetal weeks
Terminal Sac 24 weeks to birth
Alveolar period birth-8yoa -
Irreversible Glycolysis
Enzymes -
Hexokinase
PhosphoFructo Kinase = Rate Limiting Step
Pyruvate Kinase
Pyruvate Dehydrogenase -
Irreversible Gluconeogenesis
Enzymes -
PyruvateCarboxy Kinase
PEPCarboxyKinase
Fructose 1,6 BiPhosphatase
Glucose 6 Phosphatase
**muscle dose not take part in Gluconeogenesis, only takes place in the liver, kidney & GI epithelium - Pellagra
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Diarrhea, Dermatitis, Dementia
Niacin Deficiency (Vit B3 deficiency)
HartnupÂ’s Disease
Malignant Carcinoid Syndrome
INH use - Lactose formers
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1. “CEEK”
2. Citrobacter
3. Enterobacter
4. E.Coli (K1 capsule most important)
5. Klebsiella - Non lactose formers
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6. “SHYPS”
7. Shigella: motile H2S+
8. Yersinia enterolytica (AKA Pestis): motile H2S+
9. Proteus: nonmotile, no H2S
10. Salmonella: nonmotile, no H2S - May lack color
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11. “These rascals may microscopically lack color”:
12. Treponema
13. Ricksetta
14. Mycobacterium
15. Mycoplasma
16. Legionella
17. Chlamydia - inc cAMP
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18. "CAPE"
19. Cholera
20. Anthracis (Poly D glutamate capsule)
21. Pertusis (via Gi)
22. E.coli (LT enterotoxin) - Have Capsules [ieÂ… are Quellung Reaction (+)]
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23. “Some killers have pretty nice capsules”
24. Strep. Pneumoniae
25. Klebsiella
26. HiB
27. Pseudamona Aeroginosa
28. Neisseria meningitis
29. Cryptococcus neoformans (only encapsulated fungal pathogen) - Dimorphic Fungi
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30. "Can Also Have Both Shapes"
31. Cocciodes
32. Aspergillus
33. Histolpasma
34. Blastomyces
35. Sprothrix schenkii - Have â Prophage
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36. "OBED"
37. O = Salmonella
38. B = Botulinum
39. E = Erythrogenic strep
40. D = Diptheria - Pigment Producing Bacteria
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56. Serratia – red (can cause pseudohemoptysis)
57. Pseudomonas A – piocyanin blue/green
58. Staph Aureus – yellow – Protein A
59. Mycobacteria – photo/scoto chromogenic – caritinoid – yellow/orange
60. Corneybacterium D – black/gray – pseudomembrane plaque in throat
61. Bacteroides (Porphyromonas) melaninogenicus – black (heme)
62. E. coli – irredescent green sheen - Bacterial Morphology
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63. Pneumococci – lancet shaped diplococci
64. Neisseria – kidney bean shaped diplococci
65. Camphylobacter - gulls - wings/comas
66. Vibrio Cholera - coma shaped
67. Corneybacterium D - club shaped (nonmotile, G+Rod)
68. Yersinia - safety pin seen in Wayson's stain - Inclusion Bodies
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69. Rabies – Negri bodies – intracytoplasmic
70. Pox virus – Guarnieri – intracytoplasmic & acidophilic
71. CMV – Owl’s eyes – intracytoplasmic & intranuclear
72. HSV – Cowdry bodies – intranuclear - Urease (+)
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82. All Proteus – can cause Staghorn/Struvite calculi (NH4
- Mg2- stones): alkaline urine
83. Ureaplasma
84. Campylobacter pylori (Helicobacter)
85. Cryptococcus
86. Nocardia - Mycoplasma
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94. No cell wall. Membrane has cholesterol. Smallest living bacteria.
95. P1 protein inhs ciliary action
96. Fried egg colonies
97. Atypical pneumonia – young adults - Need Cysyeine for growth
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107. “Ella likes cysteine”:
108. Francisella
109. Brucella
110. Legionella
111. Pasturella - Chlamydiae Developmental Cycle
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181. Elementary Body: infeccious particle that Enters the cell
182. Reticulate Body: made from elementary body. Replicates, differentiates and releases
elementary bodies to infect other cells
183. W/ infection you will see Glycogen containing inclusions
184. Cell wall lacks muramic acid - Orthomyxovirus
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212. –ssRNA, enveloped virus.
213. Spike Glycoproteins (peplomeres): HA = Hemagluttinin & NA = Neuraminidase. These
peplomeres are what give the virus antigenis variation
214. Influenza A & B - Paramyxovirus
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215. –RNA, enveloped. Most common cause of respiratory infections in kids
216. Mumps
217. Croup(Parainfluenza virus)
218. Rubeola(Measles virus)
219. RSV - Togavirus
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220. +ssRNA, enveloped
221. 3 Day Measles: German Measles: Rubella/ Rubivirus
222. Encephalitis viruses: Alphaviruses: Eastern (more severe) and Western Equine
Encephalitis - Flaviviris
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223. Dengue Fever - icterus & hemorrhage w/ blac vomit
224. Yellow fever
225. St. Louis Encephalitis – no hepatitis or hemorrhage - Bunyavirus
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226. –ssRNA, enveloped
227. California Encephalitis – severe bifrontal headaches
228. Hantavirus – hemorrhagic fever w/ acute resp. distress syndrome - IgA Protease Activity
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229. H. Influenzae (needs factors V & X for growth)
230. Strep. Pneumoniae
231. N. meningitidis
232. N. gonnorhoae
233. W/ this activity these bugs are able to colonize the oral mucosa. - Diphtheria: ABCDEFG
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234. Adenopathy
235. â Prophage encodes the exotoxin
236. Corneybacteria is Club shaped
237. Diphtheria
238. Elongation Factor II
239. Granules (metachromatic) - "Hot T-Bone stEAk": ILs
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IL1 = inc Temp: HOT
IL2 = stimulate T cells
IL3 = stimulate Bone Marrow stem cells's growth & differentiation (GM CSF)
IL4 = stimulate IgE (& IgG)
IL5 = stimulate IgA (& eosinophils) - Plasmodium Life Cycle
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Sporozoites: from blood to liver
Primary tissue schizont
Trophozoites: in RBC
Erythrocytic schizont
Merozoite: ruptured RBC
Gametozyte
Zygote: inside the mosquito