I&I viruses from infection & immunity
Terms
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- Virus families with double stranded DNA
-
Herpes
Hepadeno
Adeno
(Parvo-actually ss)
Papova
Pox
(not Picorna or Paramyxo) - Members of Herpes virus family
-
Double Stranded, Enveloped, Icosahedral
Herpes simplex
Varicella
EBV
CMV
HHV-6 & 8 - HSV
-
double stranded, enveloped,
dx w/Tzank or immunoflouresc
acyclovir (b/c thymadine kinase- also in Varicella) - EBV
-
double stranded, enveloped
infect B lymphocytes
Burkitt's & Nasal Carcinoma
Hairy Oral Leukoplakia
(in immunocomp'd)
splenomegaly & reactive T cells - CMV
-
double stranded, enveloped
in AIDS & transferred via
breast milk
Ganciclovir - HHV 6 is associated with...
- Roseola
- HHV 8 is associated with...
- Kaposi Sarcoma
- Characteristics of Adenovirus
-
double stranded, naked, icosahedral
penton fibers are attachment
sites
travel & replicate in nodes - Characteristics of Papova
-
double strand, circular DNA
naked, icosahedral
Papilloma virus (HPV) is
family member - HPV
-
member of Papovavirus family
serotype 16 & 18 associated with cervical Ca - Characteristics of Pox Virus
-
Complex structure
Largest virus
linear, ds, DNA, enveloped
RNA AND DNA polymerase
replicate in cytoplasm - members of Pox family
-
Variola (small pox)
Molluscum Contagiosum - Characteristics of Hepadenavirus
-
ds, enveloped DNA
includes HBV - Characteristics of Parvovirus
-
sm, ss DNA
serotype B19 is the only
human pathogen
Fifth Disease - Fifth Disease
-
caused by a Parvovirus
slap cheek rash
aplastic crisis w/chronic
hemolytic dz- (thalassemia
anemia)
Hydrops Fetalis - RNA Virus Characteristics
-
Replicate in Cytoplasm except
influenza & retrovirus
Single Stranded except Reo
Enveloped except Reo, Calci &
Picorna
Antisense (neg strand) are
all helical, enveloped, ss - DNA Virus Characteristics
-
Replicate in Nucleus except
Pox
Double stranded except Parvo
(hepadeno has ss regions)
Icosahedral except Pox - RNA Virus Families
-
Ico, Enveloped, SS
Toga & Flavi
Ico, NE, ds- Reo
Ico, NE, ss- Picorna & Calci
Helical, E, SS- ROBCRAP
Rhabdo, Ortho, Bunya, Corona, Arena, Paramyxo
Retro - Characteristics of Picornavirus
-
ss, +RNA, naked
Entero: polio, coxsackie, echo & entero
Rhino- common cold (w/adeno) - Poliovirus
-
member of Picorna
binds Rs in gut & neurons
polycistronic (proteases)
flaccid paralysis - Echovirus
-
member of Picorna
throat infections in summer
months - Coxsackie Virus
-
member of Picorna
epidemics in summer & fall
may cause meningitis
A- "Hand-Foot-Mouth"
B- myocarditis - Enterovirus
-
member of Picornavirus
72 is causative agent for
Hep A - Rhinovirus
-
member of Picorna
causes cold (like adeno) - Characteristics of Orthomyxo Family
-
-RNA, ss, segmented, enveloped
Influenza A & B - Influenza A & B
-
members of Orthomyxo family
segmented RNA
M (matrix)protein- maturation
NM (nucleocapsid) protein
Hemagluttin & Neuramidase are
targets for immune response
B associated with Reyes synd - Treatment for influenza
-
A- amantadine & rimantadine
A & B- oseltamivir & zamivir - Characteristics of Paramyxovirus
-
-RNA, enveloped
initial infection via resp
most common cause resp inf in children
HN protein (neuraminidase & hemagglutinin)- attachment
M protein- inner layer
F protein- fusion & hemolytic - Members of Paramyxovirus Family
-
Parainfluenza- croup
Measles (rubeola)
Mumps
RSV - Parainfluenza Virus
-
member of paramyxovirus
causes croup - Measles Virus
-
member of paramyxovirus
fever & maculopapular exanthem
Koplik spots- bluish-white specks on red base in buccal mucosa
coryza, conjunctivitis & cough - Mumps Virus
-
member of Paramyxovirus
vaccine is live attenuated - RSV
-
member of paramyxovirus
primary cause lower resp inf in infants
aerosolized droplets & fomites - Characteristics of Togavirus
-
+RNA, ss, enveloped
glycoprotein hemagglutinins in envelop - Members of Togavirus family
-
Alphavirus- EEE & WEE- arthropod-borne, spred via insect vector
Rubivirus (Rubella)- can transmit across placenta - Characteristics of Flavivirus
-
+RNA, ss, enveloped
similar to Togavirus
arthropod-borne - Members of Flavivirus family
-
Yellow Fever- mosquito
Dengue Fever- mosquito
St. Louis encephalitis - Yellow Fever
-
member of Flavivirus family
mosquito borne
hepatitis & hemorrhagic
(like dengue) - Dengue Fever
-
member of Flavivirus Family
mosquito borne
hepatitis & hemorrhagic
(like yellow) - St. Louis Encephalitis
-
member of flavivirus family
arthropod borne
CNS symptoms - Characteristics of Bunyavirus
-
-RNA, ss, enveloped
arthrpod vectors - members of Bunyavirus
-
California Encephalitis
Hanta - California Encephalitis
-
member of bunyavirus
-RNA, ss, enveloped
abrupt fever, bifrontal HA
arthropod vector - Hanta Virus
-
member of Bunyavirus
-RNA, ss, enveloped
hemorragic fever & ARDS - Characteristics of Rhabdoviruses
-
bullet shaped enveloped -RNA
ss
nucleocapsid w/glycoprotein spikes
replicates in cytoplasm - Rabies
-
Member of Rhabdovirus
-RNA, bullet shape, envel, ss
glycoproteins are immunologic target
prodrome, sensory, excitement, paralytic - Characteristics of Coronavirus
-
+RNA, ss, enveloped
club shaped projections
common cold - Characteristics of Calcivirus
-
member of calcivirus
+RNA, ss, enveloped
gastroenteritis (common cause) epidemics
Hep E is very similar - Characteristics of Arenaviruses
-
segmented, ss, -RNA, enveloped
chronic carrier state
Lymphocytic choriomeningitis
Lassa - Lymphocytic Chroiomeningitis Virus
-
Member of Arenovirus
segmented, ss, -RNA, env
transmitted by rodents - Lassa fever
-
member of arenovirus
segmented, +RNA, ss, env
rodent
high mortality - Characteristics of Filoviruses
-
-RNA, ss, enveloped
filamentous
Marburg & Ebola - Marburg
-
member of Filovirus
-RNA, ss, enveloped - Ebola
-
membere of Filovirus
-RNA, ss, enveloped - Characteristics of Reovirus
-
ds, seg'd RNA, naked
URI & GI
Rotavirus- diarrhea in infant
Orbivirus- Co Tick Fever - Rotavirus
-
member of Reovirus
ds, seg'd RNA, naked
major cause of diarrhea in infants - Characteristics of Retrovirus
-
diploid, ss, +RNA, enveloped
2 copies ss RNA
reverse transcriptase
Pol, Env, Gag proteins
HTLV & HIV