Virology Final UIUC
Terms
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- What are the main diseases for Paramyxoviridae
-
Parainfluenza Type 1-4
Newcastle disease virus (NDV; Avian PMV-1) – zoonotic & reportable
Canine distemper virus(CDV)
Bovine respiratory syncytial virus (BoRSV) - What are the main diseases for Coronaviridae
-
Feline Enteric Corona (FECV)
Feline Infectious peritonitis (FIPV) Transmissable Gastroenteritis (TGEV)
Bovine Corona Virus (BCV)
Infectious Bronchitis (IBV) - What are the main diseases for arterivirus
- EVAV, PRRSV
- What are the main diseases for Bunyaviridae
- Cache Valley virus – zoonotic
- What are the main diseases for Togaviridae
-
EEEV (90%), VEEV (50-80%), WEEV (20-40%)
Reportable & zoonotic - What are the main diseases for Flaviviridae
-
Bovine viral diarrhea-mucosal disease virus (BVDV)
Hog cholera virus
(HCV) - reportable
West Nile virus – zoonotic - What are the main diseases for Reoviridae
-
Bluetongue (BT) – reportable
African horse sickness (AHSV) – reportable
Rotavirus (Group A) - What are the main diseases for Birnaviridae
- Infectious bursal disease virus (IBDV, Gumboro disease)
- What are the main diseases for Picornaviridae
-
Foot-and-Mouth disease virus (FMDV) – reportable
Swine vesicular disease virus
(SVDV) – zoonotic & report.
Equine rhinovirus
Bovine rhinovirus - What are the main diseases for Caliciviridae
-
Feline calicivirus (FCV)
Vesicular exanthema of swine (VES) - reportable - What type of genome does Paramyxoviridae have, and is it (+) or (-) sense
-
ssRNA
(-) - What type of genome does Coronaviridae have, and is it (+) or (-) sense
-
ssRNA
(+) - What type of genome does Arterivirus have, and is it (+) or (-) sense
-
ssRNA
(+) - What type of genome does Bunyaviridae have, and is it (+) or (-) sense
-
ssRNA
Segmented
(-) - What type of genome does Togaviridae have, and is it (+) or (-) sense
-
ssRNA
(+) - What type of genome does Flavaviridae have, and is it (+) or (-) sense
-
ssRNA
(+) - What type of genome does Reoviridae have, and is it (+) or (-) sense
- dsRNA
- What type of genome does Birniviridae have, and is it (+) or (-) sense
- dsRNA
- What type of genome does Picornaviridae have, and is it (+) or (-) sense
-
ssRNA
+ - What type of genome does Calliciviridae have, and is it (+) or (-) sense
-
ssRNA
(+) - Is the genome for Parmyxoviridae stable or labile, and under what conditions
- labile
- Is the genome for Coronaviridae stable or labile, and under what conditions
- acid stabile
- Is the genome for Arterivirus stable or labile, and under what conditions
- labile
- Is the genome for Bunyaviridae stable or labile, and under what conditions
-
acid labile,
stable in protein - Is the genome for Togaviridae stable or labile, and under what conditions
- labile
- Is the genome for Flaviviridae stable or labile, and under what conditions
- labile
- Is the genome for Reoviridae stable or labile, and under what conditions
-
Rotovirus – pH stable &
Orbivirus – pH labile but stable 6-8 - Is the genome for Birnaviridae stable or labile, and under what conditions
- heat & pH (3-9)stable
- Is the genome for Picornaviridae stable or labile, and under what conditions
- stable
- Is the genome for Caliciviridae stable or labile, and under what conditions
- stable
- Is Paramyxoviradae enveloped and if so where does the envelope come from
-
YES
(plasma membrane) - Is Coronaviradae enveloped and if so where does the envelope come from
-
YES
(RER and/or Golgi) - Is Arterivirus enveloped and if so where does the envelope come from
-
YES
(internal organelles) - Is Bunyaviradae enveloped and if so where does the envelope come from
-
YES
(Golgi - Is Togaviradae enveloped and if so where does the envelope come from
-
YES
(cytoplasmic vesicles) - Is Flavaviradae enveloped and if so where does the envelope come from
-
YES
(RER) - Is Reoviradae enveloped and if so where does the envelope come from
- No
- Is Birnaviradae enveloped and if so where does the envelope come from
- No
- Is Picornaviradae enveloped and if so where does the envelope come from
- NO
- Is Caliciviradae enveloped and if so where does the envelope come from
- No
- Is paramyxoviridae small medium or large
- Large
- Is Coronaviridae small medium or large
- Medium
- Is Arteriviridae small medium or large
- Medium
- Is Togaviridae small medium or large
- Medium
- Is Bunyaviridae small medium or large
- Med
- Is Flavaviridae small medium or large
- Small
- Is Reoviridae small medium or large
- Medium
- Is Birnaviridae small medium or large
- Medium
- Is Picornaviridae small medium or large
- small
- Is Caliciviridae small medium or large
- small
- What is the capsid morphology of Parmyxoviridae
-
“herringbone†helical
(pleomorphic spherical or filamentous virion) - What is the capsid morphology of Coronaviridae
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Helical
(pleomorphic spherical virion) - What is the capsid morphology of Arteriviridae
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Icosahedral
(spherical virion) - What is the capsid morphology of Bunyaviridae
- Helical (spherical virion)
- What is the capsid morphology of Togaviridae
- Icosahedral (spherical virion)
- What is the capsid morphology of Flaviviridae
-
Icosahedral
(spherical virion) - What is the capsid morphology of Reoviridae
-
2 concentric capsids
I = icosahedral
O = spherical - What is the capsid morphology of Birnaviridae
- (icosahedral virion)
- What is the capsid morphology of picornaviridae
- icosahedral to spherical virion
- What is the capsid morphology of Caliciviridae
- icosahedral to spherical virion
- What is the mode of entrance for Paramyxoviridae
-
Fusion
(F protein) - What is the mode of entrance for Coronaviridae
-
Fusion
(S protein) &
RM endocytosis - What is the mode of entrance for Arterivirus
- RM endocytosis
- What is the mode of entrance for Bunyaviridae
- Fusion
- What is the mode of entrance for Togaviridae
- RM endocytosis
- What is the mode of entrance for Flaviviridae
- RM endocytosis
- What is the mode of entrance for Reoviridae
- RM endocytosis
- What is the mode of entrance for Birnaviridae
- RM endocytosis
- What is the mode of entrance for Picornaviridae
- RM endocytosis
- What is the mode of entrance for Caliciviridae
- Endocytosis
- What is the cell tropism for paramyxoviridae
-
Respiratory epithelium
GI epithelium
Neurons-CDV & NDV - What is the cell tropism for Coronaviridae
-
Repiratory epithelium
GI epithelium
Other organs
CNS infection (via nerve tract migration) - What is the cell tropism for Arterivirus
- Macrophages
- What is the cell tropism for Bunyaviridae
- Varies w/ genera
- What is the cell tropism for Togaviridae
- Neurons
- What is the cell tropism for Flaviviridae
-
BVDV = lymphoid tissue & mucosal epith.
Hog cholera = reticulo-endothelial system & endothelial cells - What is the cell tropism for Reoviridae
- Mucosal epithelium, lymphocytes, neurons
- What is the cell tropism for Birnaviridae
- BDV – pre-B lympho-cytes (Bursa) & ?Macrophages?
- What is the cell tropism for Picornaviridae
-
Epithelial cells
Host proteases (post-translational) - What is the cell tropism for caliciviridae
- Mucosal epithelium
- How does paramyxoviridae exit the cell
- Budding PM & Syncytia formation
- How does Coronaviridae exit the cell
- Exocytosis (fusion of cytoplasmic vesicles) & Syncytia formation
- How does Arterivirus exit the cell
- Bud (cytoplasmic organelles) or Cytolysis
- How does Bunyaviridae exit the cell
-
Exocytosis
Cytolysis - How does Togaviridae exit the cell
- Bud into cytoplasmic vesicles - cytolysis
- How does Flaviviridae exit the cell
- Cytolysis & Exocytosis (bud from RER)
- How does Reoviridae exit the cell
- Cytolysis
- How does Birnaviridae exit the cell
- Cytolysis
- How does Picornaviridae exit the cell
- Cytolysis
- How does Caliciviridae exit the cell
- Cytolysis
- What is the incubation period for Paramyxoviridae
-
Short
(< 2 weeks - What is the incubation period for Coronaviridae
-
Short
(1 day –
1 week) - What is the incubation period for Arterivirus
-
Short
(< 1 week) - What is the incubation period for Bunyaviridae
- ????
- What is the incubation period for Flaviviridae
-
Short
(< 1 week) - What is the incubation period for Togaviridae
-
Short
(< 1 week) - What is the incubation period for Reoviridae
-
Short
(< 1 week) - What is the incubation period for Birnaviridae
-
Short
(< 1 week)
2-3d IBDV - What is the incubation period for Picornaviridae
-
Short
(< 1 week) - What is the incubation period for Caliciviridae
- Short(< 1 week)
- How may paramyxoviridae be transmitted (i.e. horizontally, vertically, etc.)
-
Horizontal – respiratory &
O/F (NDV & CDV)
Vertical – transovarian (NDV) - How may Coronaviridae be transmitted (i.e. horizontally, vertically, etc.)
-
Horizontal only
(respiratory & O/F) - How may Arterivirus be transmitted (i.e. horizontally, vertically, etc.)
- Horizontal (respiratory, fetuses) & Vertical (transplacental & semen)
- How may Bunyaviridae be transmitted (i.e. horizontally, vertically, etc.)
- Horizontal (mosquito) & Vertical (transplacental)
- How may Togaviridae be transmitted (i.e. horizontally, vertically, etc.)
- Horizontal (mosquito) & Vertical
- How may Flaviviridae be transmitted (i.e. horizontally, vertically, etc.)
- Horizontal (O/F, urogenital, mosquito) & Vertical (transplacental & semen)
- How may Reoviridae be transmitted (i.e. horizontally, vertically, etc.)
-
Horizontal & Vertical
AHSV = horiz. only - How may Birnaviridae be transmitted (i.e. horizontally, vertically, etc.)
- Horizontal (O/F) & Vertical (in ova – minor)
- How may Picornaviridae be transmitted (i.e. horizontally, vertically, etc.)
-
Horizontal
FMDV – respiratory, milk/contaminated feed, insemination, iatrogenic
SVDV – skin abrasions, O/F - How may Caliciviridae be transmitted (i.e. horizontally, vertically, etc.)
- Horizontal (respiratory & oral)
- Where are the inclusion bodies for paramyxoviridae located in the host cell
-
Cytoplasmic
CDV- cytoplasmic & nuclear - Where are the inclusion bodies for Reoviridae located in the host cell
- +/- cytoplasmic
- Where are the inclusion bodies for Caliciviridae located in the host cell
- Cytoplasm
- What are the three families of virus that may have inclusion bodies
- Paramyxoviridae<br />Reoviridae<br />Caliciviridae
- Which family of virus may undergo intramolecular recombination
- Picornaviridae
- How many segments of RNA does Birnaviridae have
- 2
- Which family may also be known as - Respiratory enteric orphan virus
- Reoviridae
- Which 3 families may be arthropod borne
-
Togaviridae
Flaviviridae
Bunyaviridae - Which family of virus are known for causing abortion
- arterivirus
- Which family of virus are known for causing fetal and embryonic death
- Flaviviridae