MedChem3
Terms
undefined, object
copy deck
- Ergot alkaloids
-
.
.
. - properties of ergot alkaloids
-
alpha 1 antagonism= vasoconstriction,
induces labor, hallucinations - major alkaloid
- ergotamine- different effects and receptor types
- ergot tx
- migraine, contract uterine smooth muscle (induce labor, abortion)
- LSD
-
.
.
. - methylsergide
-
5HT 1,2,3,4 antag and alpha agonist
prophl. tx for migraine - bromocriptine
-
.
.
.
tx: DA d2 agonist, dec prolactin secretion from pituitary - fluoxetine
-
.
.
. - paroxetine
-
.
.
. - sertraline
-
.
.
. - SSRI's
-
all block 5HT reuptake at synapse
tx: depression - serotonin syndrome
-
hyperthermia, muscle rigidity, myoclonus
(If MAOI & SSRI) - sibutramine
-
x BBB
.
.
. - sibutramine SE's
-
inc BP, insomnia, constipation
*diastomeric mixture - fenfluramine
-
.
.
. - fenfluramine se's
- decrease in appetite (like amphetamines), inc lipoph
- fen-phen
-
fenfluramine & phentermine
.
.
.
.
problems: fatal pulm HTN, excess catech. & 5HT in periphery