Coag II
Terms
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For diagnosing bleeding disorders, what are the:
-Screen tests?
-Confirmation tests? -
Screen: PT/PTT/BT/Plt count
Confirm: plt aggregation, factor assay - What generalized systemic defects can cause prolonged pt/ptts?
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-Liver disease
-Renal disease
-Chronic cancer, etc. - How can bleeding symptoms differentiate Platelet vs. Coag factor deficiencies?
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Petichiae = PLATELETS, not coag factor.
-Also has spontaneous mucous membrane bleeding. - What's more common; acquired or hereditary coagulopathies?
- Acquired.
- What causes acquired coagulopathies?
- Aspirin, drugs, autoimmune disease, etc.
- What bleeding disorders are sex-linked recessive?
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-Hemophilia A/B
-Wiskott-Aldrich - How can the PT/PTT diff. btwn platelet/vasc disorders and Coagulation disorders?
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Platelet/vascular: PT/PTT are NORMAL
Coag: abnormal - prolonged - How does the BT differentiate them?
- BT is elevated in Plt/vasc, not in Coag factor deficiency.
- What 3 tests are used to diagnose platelet diseases?
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-Platelet aggregation
-Electrophoresis
-Genetic studies -
For coagulation defects:
-What are the screens?
-What are the diagnostic tests? -
Screens: PT/PTT
Confirm: Electrophoresis, factor assays, genetic studies. - What type of abnormality will show HEMARTHROSES?
- Coag defects; not platelet.
- How does NORMAL PLASMA correct a prolonged PT/PTT?
- -Replaces 50% of all factors!