RBC Maturation/Retic Cnts/Megakaryocytes
Terms
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- names of the RBC maturation in both terms:
-
Peanut Butter Pop
Pronormoblast, Rubriblast
Basophilic normoblast, Prorubricyte
polychromatic normoblast, Rubricyte
orthochromic normoblast, Metarubricyte
polychromatic erythrocyte (diffusely basophilic erythrocyte) - what is the last stage of RBC mat capable of division?
-
PBP
Polychromatic normiblast, aka, the RUBRICYTE. - what is the life span of a RBC?
- 120 days
- how many rbcs are senescent per day?
- 1%
- what 3defects can occur in RBC maturation?
-
-Cytoplasm - extra division of the cell can result in not enough cytoplasm for each daughter.. microcytosis.
-Nucleus - nucleas/cytoplasm develop sposed to be in synch, if nucleus doesn't divide enough, there'll be too much cytoplasm.
-Membrane/genetic - poikilocytosis - what is the retic count good for?
- it is a very sensitive measure of erythropoietic activity in the bone marrow.
- what are the two types of retics seen in a retic count?
-
-shift retics
-stress retics -
what type of stain is used for retic counts?
alternate? -
supravital: New Methylene blue
alternate: brilliant cresol - What are the hematopoeitic progenitor cells in RBC maturation?
-
-pluripotent stem cell of course - CD34
-BFU-E - burst forming for 1000 copies
-CFU-E - colony forming - what is the role of erythropoietin in RBC maturation? (3 jobs)
-
1. responds to hypoxia in kidney tissue
2. stimulates proliferation of RBC precursors - BFU-e and CFU-e
3. acts on release - how does erythropoeitin influence the CFU-E cell?
-
promotes DNA/RNA synthesis for division
helps Iron transfer to the RBCs for hemoglobin production. - What are the hematopoietic progenitors for megakaryocytes?
-
-pluripotent stem cell
-CFU-Meg - what hormone is responsible for mat/release of megakaryocytes?
- thrombopoietin
- what are the names of the maturing megakaryocytes after the progenitors?
-
Megakaryoblast
Promegakaryocyte
Megakaryocyte
Platelets - Do Megakaryocytes get bigger or smaller?
- BIGGER
- How does the nucleus develop in megakaryocytes?
-
blast - 1 single round nucleus
promega - multilobed
megakaryocyte - POLYploid!
then platelets, with no nucleus - what does "endomitosis' mean, and what megakaryocyte mat phase is it seen in?
- division of nucleus, but not the cell. the megakaryoblast.
-
Which phases have:
-1-4 nucleoli
-indistinct nucleoli -
Megakaryoblast
Promegakaryocyte - how do granules develop in the maturing megakaryocyte?
-
none in first cell,
some red granules in promeg
numerous aggregated in meg! - how many platelets per megakaryocyte?
- 2,000 to 4000