virulence factors
Terms
undefined, object
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- exotoxins produced by
- gram postiitve and negative
- endotoxins produced by
- gram NEGATIVE bacilli
-
how toxic are
exotoxins
endotoxins -
exo = STRONGLY toxic
endo = not as much -
site of toxin's effect
exo
endo -
exo = specific mode is often obscure
endo = similar toxicity for most organs/cells -
chemical nature of
endotoxins
exotoxins -
exo: protein
endo: lipopolysaccharide - chemical nature of toxin secreted by endotoxins
- cell-associated lps
-
how exotoxins are released
endotoxins? -
exo: secreted
endo: remains bound; released when cell lyses -
heat lability of
exotoxins
endotoxins -
exo = heat-labile; easy to toxoid - inactivate.
endo = heat-stabile; don't inactivate. -
host immune response to
exotoxins
endotoxins -
exo: easy to neutralize w/ antibody
endo: hard to neutralize w/ antibody -
do exotoxins produce fever/confusion in host?
do endo? -
no
yes