FA Pharm: Toxicology, Drug Rxns
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- Toxicology: What is the antidote for acetaminophen toxicity/overdose
- N-acetylcysteine
- Toxicology: What is the antidote for salicylates toxicity/overdose
- Alkanize urine/dialysis
- Toxicology: What is the antidote for antichoinesterase toxicity/overdose
- Atropine, pralidoxime
- Toxicology: What is the antidote for antimuscarinic/anticholinergic agents toxicity/overdose
- physostigimine salicylate
- Toxicology: What is the antidote for Beta-blockers toxicity/overdose
- glucagon
- Toxicology: What is the antidote fordigitalis toxicity/overdose
- Stop digitalis, Normalize K+, lodpcaine, anti-digitialis Fab Fragments, Magnesium
- Toxicology: What is the antidote for lead toxicity/overdose
- CaEDTA, dimercaprol, succimer, penicillamine
- Toxicology: What is the antidote for iron toxicity/overdose
- Deferoxamine
- Toxicology: What is the antidote for aresnic/mercury/gold toxicity/overdose
- Dimercaprol (BAL), succimer
- Toxicology: What is the antidote for copper, arsenic, gold toxicity/overdose
- Penicillamine
- Toxicology: What is the antidote N-acetylcysteine used to treat?
- Acetaminophen toxicity/overdose
- Toxicology: What is the antidote for cyanide toxicity/overdose
- nitrite, hydroxocobalamin, thiosoulfate
- Toxicology: What is the antidote for methemoglobin toxicity/overdose
- methylene blue
- Toxicology: What is the antidote glucagon used to treat?
- Beta-blocker toxicity/overdose
- Toxicology: What is the antidote for carbon monoxide toxicity/overdose
- 100% oxygen, hyperbaric oxygen
- Toxicology: What is the antidote atropine used to treat?
- anticholinesterase toxicity/overdose
- Toxicology: What is the antidote for methanol toxicity/overdose
- Ethanol, dialusis, fomepizole
- Toxicology: What is the antidote for opiods toxicity/overdose
- Nalozone/naltrexone
- Toxicology: What is the antidote for ethylene glycol toxicity/overdose
- Ethanol, dialusis, fomepizole
- Toxicology: What is the antidote for benzodiazepines toxicity/overdose
- Flumazenil
- Toxicology: What is the antidote for (TCA) Tricyclic Antidepressants toxicity/overdose
- NaHCO3
- Toxicology: What is the antidote for Heparin toxicity/overdose
- Protamine
- Toxicology: What is the antidote Deferoxamine used to treat?
- Iron toxicity/overdose
- Toxicology: What is the antidote for warfarin toxicity/overdose
- vitamin K, fresh frozen plasma
- Toxicology: What is the antidote Naloxone/naltrexone used to treat?
- opioid toxicity/overdose
- Toxicology: What is the antidote for tPA/streptokinase toxicity/overdose
- aminocaproic acid
- Toxicology: What is the antidote Physostigmine salicylate used to treat?
- Antimuscarinic/anticholinergic agents toxicity/overdose
- Toxicology: What is the antidote Flumazenil used to treat?
- Benzodiazepine toxicity/overdose
- Toxicology: What is the antidote Protamine used to treat
- Heparin toxicity/overdose
- Toxicology: Children living in old houses might eat the paint chips which could cause ____
- Lead Poisoning
- Toxicology: Signs of Lead poisoning include:
- Lead Lines on gingivae and epiphyses of Long bones, Encephalopathy and Erythrocyte Basophilic stipling, Abdominal colic and sideroblastic Anemia, Wrist and Foot Drop
- Toxicology: 1st line of Treatment for Lead Poisoning include
- Dimercaprol and EDTA
- Toxicology: Weak acids, such as phenobarbitol, methotreaxate, aspirin, alkanize urine with ____ to increase clearance
- bicarbonate
- Toxicology: Weak bases, such as amphetamines, acidify urine with NH4Cl to ____ clearance
- increase
- Toxicology: AUTHOR
- Lakshmi Swamy
- Drug reactions: For each drug reaction, give the pharmacological agents responsible. The number of drugs you should list are given in parentheses. You could also quiz yourself in reverse by going down the list of drugs on the right.
- 0
- Drug reactions: Pulmonary fibrosis (3)
- bleomycin, amiodarone, busulfan
- Drug reactions: Hepatitis (2)
- isoniazid, halothane
- Drug reactions: Focal to massive hepatic necrosis (4)
- halothane, valproic acid, acetaminophen, amanita phalloides
- Drug reactions: Anaphylaxis (1)
- penicillin
- Drug reactions: SLE-like syndrome (4). [mnemonic: it's not HIPP to have lupus]
- hydralazine, INH, procainamide, phenytoin
- Drug reactions: Hemolysis in G6PD-deficient patients (8)
- sulfonamides, INH, aspirin, ibuprofen, primaquine, nitrofurantoin, pyrimethamine, chloramphenicol
- Drug reactions: Thrombotic complications (1 class)
- OCPs (e.g. estrogens and progestins)
- Drug reactions: Adrenocortical insufficiency (withdrawal of what class of drugs causes adrenocortical insufficiency?)
- withdrawal of glucocorticoids causes hypothalamic-pituitary-axis supression
- Drug reactions: Photosensitivity reactions (3) [mnemonic: SAT for a photo]
- Sulfonamides, amiodarone, tetracycline
- Drug reactions: Induce P-450 system (6)
- barbiturates, phenytoin, carbamazepine, rifampin, griseofulvin, quinidine
- Drug reactions: Inhibit P-450 system (6, including one fruit)
- cimetidine, ketoconazole, grapefruit, erythromycin, INH, sulfonamides
- Drug reactions: Tubulointerstitial nephritis (5)
- sulfonamides, furosemide, methicillin, rifampin, NSAIDs (except aspirin)
- Drug reactions: Hot flashes (1)
- Tamoxifen
- Drug reactions: Cutaneous flushing (4)
- niacin, Ca++ channel blockers, adenosine, vancomycin
- Drug reactions: Cardiac toxicity (2)
- doxorubicin (adriamycin), daunorubicin
- Drug reactions: Agranulocytosis (3, all start with letter C)
- clozapine, carbamazepine, colchicine
- Drug reactions: Stevens-Johnson syndrome (3)
- ethosuximide, sulfonamides, lamotrigine
- Drug reactions: Cinchonism (2)
- quinidine, quinine
- Drug reactions: Tendonitis, tendon rupture and cartilage damage (kids) (1)
- fluoroquinolones
- Drug reactions: Disulfiram-like reaction (4)
- metronidazole, certain cephalosporins, procarbazine, sulfonylureas
- Drug reactions: Otoxicity and nephrotoxicity (3)
- aminoglycosides, loop diuretics, cisplatin
- Drug reactions: Drug-induced Parkinson's (4)
- haloperidol, chlorpromazine, resperine, MPTP
- Drug reactions: Torsades de pointes (two subclasses of antiarrhythmics)
- Class III (sotalol), class IA (quinidine) antiarrhythmics
- Drug reactions: Aplastic anemia (3)
- chloramphenicol, benzene, NSAIDs
- Drug reactions: Neuro/nephrotoxicity (1)
- polymyxins
- Drug reactions: Pseudomembranous colitis (2)
- clindamycin, ampicillin
- Drug reactions: Gynecomastia (5) [mnemonic: Some Drugs Create Awesome Knockers]
- spironolactone, digitalis, cimetidine, chronic Alcohol use, estrogens, ketoconazole
- Drug reactions: Atropine-like side effects (1)
- tricyclics
- Drug reactions: Cough (1)
- ACE inhibitors (losartan --> no cough)
- Drug reactions: Gingival hyperplasia (1)
- phenytoin
- Drug reactions: Diabetes insipidus (1)
- lithium
- Drug reactions: Tardive dyskinesia (1)
- antipsychotics
- Drug reactions: Fanconi's syndrome (1)
- tetracycline
- Drug reactions: Gray baby syndrome (1)
- chloramphenicol
- Drug reactions: Extrapyramidal side effects (3)
- chlorpromazine, thioridazine, haloperidol
- Drug reactions: Osteoporosis (2)
- corticosteroids, heparin
- Alcohol toxicity: Ethylene glycol is converted to ------- ------ by alcohol dehydrogenase. This product can lead to acidosis and nephrotoxicity.
- oxalic acid.
- Alcohol toxicity: Alcohol dehyrogenase also converts methanol to formaldehyde and formic acid, which can cause severe ----- and damage to the -------.
- acidosis. retina
- Alcohol toxicity: Ethanol competes with ethylene glycol and methanol (if present) for alcohol dehydrogenase. ADH action on EtOH produces -------.
- acetaldehyde
- Alcohol toxicity: What symptoms does acetaldehyde cause?
- nausea, vomiting, headache, hypotension
- Alcohol toxicity: Acetaldehyde itself can be metabolized by acetaldehyde dehydrogenase to ----- -----.
- acetic acid.
- Alcohol toxicity: Acetaldehyde dehydrogenase is inhibited by what drug?
- disulfiram.
- Herbal agents: Give the clinical uses for the following herbal agents.
- 0
- Herbal agents: echinacea clinical use
- common cold
- Herbal agents: ephedra clinical use
- as for ephedrine
- Herbal agents: feverfew clinical use
- migraine
- Herbal agents: ginko clinical use
- intermittent claudication
- Herbal agents: kava clinical use
- chronic anxiety
- Herbal agents: milk thistle clinical use
- viral hepatitis
- Herbal agents: saw palmetto clinical use
- benign prostatic hyperplasia
- Herbal agents: St. John's wort clinical use
- mild to moderate depression
- Herbal agents: dehyroepiandrosterone clinical use
- symptomatic improvement in females with SLE or AIDS
- Herbal agents: Melatonin clinical use
- jet lag, insomnia
- Herbal agents: Give the toxicities for the following herbal agents.
- 0
- Herbal agents: echinacea toxicity
- GI distress, dizziness, and headache
- Herbal agents: ephedra toxicity
- CNS and cardiovascular stimulation; arrhythmias, stroke and seizures at high doses.
- Herbal agents: feverfew toxicity
- GI distress, mouth ulcers, antiplatelet actions
- Herbal agents: ginko toxicity
- GI distress, anxiety, insomnia, headache, and antiplatelet actions
- Herbal agents: kava toxicity
- GI distress, sedation, ataxia, hepatotoxicity, phototoxicity, dermatotoxicity
- Herbal agents: milk thistle toxicity
- loose stools
- Herbal agents: saw palmetto toxicity
- GI distress, decreased libido, hypertension
- Herbal agents: St. John's wort toxicity
- GI distress and phototoxicity; serotonin syndrome with SSRIs
- Herbal agents: dehyroepiandrosterone toxicity
- Androgenization (premenopausal women), estrogenic effects (postmenopausal), feminization (young men)
- Herbal agents: Melatonin toxicity
- Sedation, supresses midcycle LH, hypoprolactinemia
- Drug category: For each drug name ending, give the general category of drug it indicates and an example of a drug in that category.
- 0
- Drug category: -ane
- inhalational general anesthetic. Halothane
- Drug category: -azepam
- benzodiazepine. Diazepam
- Drug category: -azine
- phenothiazine (neuroleptic, antiemetic). Chlorpromazine
- Drug category: -azole
- antifungal. Ketoconazole
- Drug category: -barbital
- barbiturate. Phenobarbital
- Drug category: -caine
- local anesthetic. Lidocaine
- Drug category: -cillin
- penicillin. Methicillin
- Drug category: -cycline
- antibiotic, protein synthesis inhibitor. Tetracycline
- Drug category: -ipramine
- tricyclic antidepressant. Imipramine
- Drug category: -navir
- protease inhibitor. Saquinavir
- Drug category: -olol
- beta antagonist. Propranolol
- Drug category: -operidol
- butyrophenone (neuroleptic). Haloperidol
- Drug category: -oxin
- cardiac glycoside (inotropic agent). Digoxin
- Drug category: -phylline
- methylxanthine. Theophylline
- Drug category: -pril
- ACE inhibitor. Captopril
- Drug category: -terol
- beta-2 agonist. Albuterol
- Drug category: -tidine
- H2 antagonist. Cimetidine
- Drug category: -triptyline
- tricyclic antidepressant. Amitriptyline
- Drug category: -tropin
- pituitary hormone. Somatotropin
- Drug category: -zosin
- alpha-1 antagonist. Prazosin