Translation of Proteins USMLE Step 1
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- What drug blocks initiation?
-
Aminoglycosides
Blocks the small 30S subunit
and doesn't let the tRNA hook into the P site - What is another drug that blocks initiation?
- Tetracycline
- What is the effect of tetracycline?
-
Blocks AminoAcyl-tRNA from binding to the A site
30S subunit - What is the neumonic for translation blocker drugs?
- buy AT 30 CELL at 50
- What blocks peptidyl transferase in the Large 50S subunit?
- Chloramphenicol
- What is the action of peptidyl transferase?
-
it forms peptide bond on the A site
takes the tRNA a.a. from the P site to the A site - Who blocks transLOcase?
- macrOLides
- What is the function of macrOLides?
- blocks the movement of tRNA from A site to the P site for elongation
- What 3 drugs block the 50S subunit?
-
Chloramphenicol
Erythromycin (Macrolides)
Lincomycin
CLindamycin - What two bacteria inhibit translation?
-
Diphtheria toxin
Pseudomonas - Where exactly do diphtheria and pseudomonas act?
- EF-2 via ADP ribosylation reaction