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Drug Interactions


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bleomycin, amiodarone, busulfan
Pulmonary fibrosis (3)
isoniazid, halothane
Hepatitis (2)
halothane, valproic acid (used intonic and absence seizures), acetaminophen, amanita phalloides
Focal to massive hepatic necrosis (4)
Anaphylaxis (1)
hydralazine, INH, procainamide, phenytoin
SLE-like syndrome (4). [mnemonic: it's not HIPP to have lupus]
sulfonamides, INH, aspirin, ibuprofen, primaquine, nitrofurantoin, pyrimethamine, chloramphenicol
Hemolysis in G6PD-deficient patients (8)
OCPs (e.g. estrogens and progestins)
Thrombotic complications (1 class)
withdrawal of glucocorticoids causes hypothalamic-pituitary-axis suppression
Adrenocortical insufficiency (withdrawal of what class of drugs causes adrenocortical insufficiency?)
Sulfonamides, amiodarone, tetracycline
Photosensitivity reactions (3) [mnemonic: SAT for a photo]
barbiturates, phenytoin, carbamazepine, rifampin, griseofulvin, quinidine
Induce P-450 system (6)
cimetidine, ketoconazole, grapefruit, erythromycin, INH, sulfonamides
Inhibit P-450 system (6, including one fruit)
sulfonamides, furosemide, methicillin, rifampin, NSAIDs (except aspirin)
Tubulointerstitial nephritis (5)
Hot flashes (1)
niacin, Ca++ channel blockers, adenosine, vancomycin (red man syndrome)
Cutaneous flushing (4)
doxorubicin (adriamycin), daunorubicin
Cardiac toxicity (2)
clozapine (atypical antipsychotic), carbamazepine(monitor LFT weekly), colchicine
Agranulocytosis (3, all start with letter C)
ethosuximide, sulfonamides, lamotrigine
Stevens-Johnson syndrome (3)
quinidine, quinine
Cinchonism (2)
Tendonitis, tendon rupture and cartilage damage (kids) (1)
metronidazole, certain cephalosporins, procarbazine, sulfonylureas
Disulfiram-like reaction (4)
aminoglycosides, loop diuretics, cisplatin
Otoxicity and nephrotoxicity (3)
haloperidol, chlorpromazine, resperine (blocks the formation of dopamine or NE from tyrosine), MPTP
Drug-induced Parkinson's (4)
Class III (sotalol), class IA (quinidine) antiarrhythmics
Torsades de pointes (two subclasses of antiarrhythmics)
chloramphenicol, benzene, NSAIDs

Parvo virus B19
Aplastic anemia (3) and a virus
Neuro/nephrotoxicity (1)
clindamycin, ampicillin
Pseudomembranous colitis (2)
spironolactone, digitalis, cimetidine, chronic Alcohol use, estrogens, ketoconazole
Gynecomastia (5) [mnemonic: Some Drugs Create Awesome Knockers]
Atropine-like side effects (1)
ACE inhibitors (losartan --> no cough)
Cough (1)
Gingival hyperplasia (1)
Diabetes insipidus (1)
Tardive dyskinesia (1)

impaired proximal tubular reabsorption 2° to lead poisoning or Tetracycline (glycosuria, hyperphosphaturia, aminoaciduria, systemic acidosis)
Fanconi's syndrome (1)
Gray baby syndrome (1)
chlorpromazine, thioridazine, haloperidol (these are all typical antipsychotics)
Extrapyramidal side effects (3)
corticosteroids, heparin
Osteoporosis (2)
Monday Disease ·
Nitroglycerin Industrial exposure ® tolerance during week ® loss of tolerance during weekend ® headache, tach, dizziness upon re-exposure
Orange Body Fluids ·
Red Man Syndrome ·
Severe HTN with Tyramine ·
Aspirin and Quinidine
Tinnitus ·

Deck Info