Pharm Stimulants
Terms
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- amphetamine structure
- similar to NE
- ampetamine mechanism of action
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indirect sympathomimetic amine
causes massive relase of NE DA and 5-HT - treatment of amphetamine intox
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nitroprusside or alpha blocker for BP
sedative - amphetime use
- hypersomnia
- alternative to amphetamine for hypersomnia
- modafinil
- orlistat
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weight loss drug
pancreatic lipase inhibitor - sibutramine
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weight loss druG
inhibits 5-HT and NE reuptake
enhances satiety and thermogenesis - methylphenidate
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ADHD
related to amphetamine
ritalin - mechanism of action of cocaine
- blocks uptake of NE, DA, 5-HT
- modafinil
- alternative to amphetime for hypersomnia treatment
- how to allevaite cocaine induced psychosis
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neuroleptics
DA receptor antagonists - methylxanthine
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alkaloid in tea, coffee, cocoa
increased alertness
respiratory stimulation
convulsive potential at high dose - mechanism of action of methylxanthine
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competitive inhibition of CNS adenosine A1 and A2 receptors
inhibits PDE and increases cAMP and high dose - medical use of methylxanthine
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asthma
apnea - examples of methylxanthine
- caffeine, theophylline, theobromine
- nicotine low dose effects
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activate nicotninc receptor subtypes in autonomic ganglia, lungs, airway, and CNS
no NMJ affect - nicotine high dose effects
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acts on all nicotinic receptors
depolarizing blockade and receptor denesitization at autonomic ganglia nd NMJ - overdose of nicotine
- cardivascular collapse, muscle weakness, respiratory failure