DM 2
Terms
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- Rapid acting insulins are
-
Lispro-humalog
Aspart-novolog - short acting insulins are
-
regular-human
regular-purified - NPH
- NPH Lletin II (pork)
- Human
- humulin L, novolin L
- Lente (insulin zinc susp)
- Lente llentin II (pork)
- Ultralente (extended insulin zinc suspenion; human)
- uhlimin U, ultralente
- Insulin glargine
- Lantus
-
Insulin secretagouges AE
stimulates pancreatic beta cells to secrete insulin - GI, hematologic, sulfa allergy, SIADH, wt gain, hypoglycemia
- Dymelor
- acetohezamide
- Diabenese
- chlorpropamide
- Tolinase
- tolazamide
- Orinase
- tolbutaimide
- Amaryl
- glimepiride
- Glocotrol, Glucotrol XL
- glipizide
- Diabeta/ Micronase
- glyburide
- Glynase
- glyburide micronized
-
enzyme inhibitors, alpha glucosidase inhibitors
MOA - delays carbohydrate metabolism and absoprtion
-
Precose
SE: -
acarbose
GI and increased LFTs - Glyset
-
miglitol
GI and decrease iron - Insulin sensitizers MOA
- increase hepatic and peripheral insulin sensitivity and decreases hepatic glucose production
- Glucophage
-
metformin
GI, megaloblastic anemia, lactic acidosis -
Thiazoladinediones
MOA - increases skeletal muscle, adipose tissue, and live insulin sensitivity and decreases hepatic glucose production
- Actos
- prioglitazone
- avandia
- rosiglitazone
- rezulin
- troglitazone
- what are the SE"s of the thiazoladinediones?
- edema, anemia, wt gain, exacerbation of CHF, URIs, resumption of ovulation
-
insulin sensitizers
meglitinides/nonsulfonylurea secretagouges
MOA - stimulates prancreatic beta cells to secrete insulin
- Prandin
- repaglinide
- starlix
- natglinide
-
what are the SE's of this class of drugs?
insulin sensitizers
meglitinides/nonsulfonylurea secretagouges - hypoglycemia, wt gain, URIs, GI, arthropathy, back pain, dizziness, flu symptoms
- Combination therapy are
- the second generation sulfonylurease or TZD and biguanides
- Glucovance
- glyburide and metformin
- metaglip
- glipizide and metformin
- Avandamet
- rosiglitazone and metformin
- Diagnosis of hypothyroidism
-
plasma TSH assay is the initial test
TSH levels elevated
low plasma-free T4 - levothryoxine sodium (t4)
- synthroid, levthroid, levoxyl, unithroid, thyro-tabs
- Armour Thyroid, nature throid, westhroid
- desiccated thyroid USP
- Cytomel, Triostat
- liothyronine (t3)
- thyrolar
- liotrix (t4 and t3)
- PTU
- propylithiouracil
- tapazole
- methimazole
- Lugol's Solution
- Strong iodine solution
- SSKI
- saturated solution of potassium iodide
- Nizoral
- ketoconazole
- cytadren
- aminoglutethimide
- Lysodren
- Mitotane
- Metopirone
- Metyrapone
- Cortone
- cortisone
- cortel, hydrocortone, solu-cortel
- Hydrocortisone
- Deltasone, Liquid Pred
- Prednisone
- Pretone, Pediapred, Delta Cortel
- Prednisolone
- Medrol, Solu-Medrol, Depo-Medrol, A-methapred
- Methylprednisolone
- Aristocort, Kenacort, Kenalog
- Triamcinolone
- Decadron, Dexameth, Dexone, Hexadrol
- Dexamathasone
- Celestone
- Betamethasone
- Florinel
- Fludrocortisone
- Costrosyn
- Cosyntropin
- Acthar (ACTH)
- Cortosotropin
- Vasopressin
- Pitressin
- Desmopressin
- Stimate (DDAVP)