Autonomic NS
Terms
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- Nicotinic Receptors
-
-ACh receptor
-blocked by curare on skeletal muscles
-blocked by hexamethonium on ANS ganglion - Muscarinic Receptors
-
-ACh receptor
-blocked by atropine on cardiac and smooth muscle and glands - Alpha-1 Receptors
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-NE receptor
-activation leads to contraction of smooth muscle in blood vessels - Alpha-2 Receptors
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-NE receptor
-Found on adrenergic presynaptic membrane
-Acts as an autoreceptor for NE to inhibit further release - Beta-1 receptors
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-NE receptor
-activation increases heart rate and force of contraction - Beta-2 receptor
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-NE receptor
-activation relaxes GI tract smooth muscle and some vascular smooth muscle - Neurotransmitters used in ANS
- ACh, NE, ATP/adenosine, NO, Serotonin, Dopamine, GABA
- Termination of NE action in ANS
-
1. Re-uptake of NE by active transport (70%) folloed by breakdown with MAO
2. Diffusion of NE from synaptic cleft into capillaries
3. Extra-neuronal uptake of NE followed by MAO beakdown - Neurotransmitter used between per-and post-ganglionic cells of ANS
- Acetylcholine
- NT released by adrenal medulla
-
NE (20%), Epi(80%)
*only innervated by sympathetic division