lymphomas and leukemias
Terms
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- What are the chronic leukemias associated with T-lymphoblasts?
- Sezary Syndrome, CLL-T (both L2)
- What are the acute leukemias associated with T-lymphoblasts?
- ALL-T (L2), ALL-null (L1), ALL-common(L1)
- What are the chronic leukemias associated with B-lymphoblasts?
- CLL-B (L3)
- What are the acute leukemias associated with B-lymphoblasts?
- ALL-B (L3)
- What are the chronic leukemias associated with monoblasts?
- Chonic monocytic (M5), chronic myelomonocytic (M4)
- What are the acute leukemias associated with monoblasts?
- Acute monocytic (M5), acute myelomonocytic (M5)
- What are the chronic leukemias associated with myeloblasts?
- CML (M1, 2 and 3), Polycythemia rubra vera (M1), myelofibrosis (M1)
- What are the acute leukemias associated with myeloblasts?
- AML (M2 and M1), Promyelocytic (M1)
- What are the chronic leukemias associated with eos-myeloblasts?
- Eosinophilic (rare)
- What are the chronic leukemias associated with normoblasts?
- Chronic erythroid (M6, rare)
- What are the acute leukemias associated with normoblasts?
- acute erythroleukemia (M6)
- What are the chronic leukemias associated with megakaryoblasts?
- Idiopathic thrombocytopenia (M7)
- What are the acute leukemias associated wwith megakaryoblasts?
- acute megakaryocytic leukemias (M7)
- What type of cell proliferates in MM, and what is its histologic appearance
- Monoclonal plasma cell, fried egg appearance
- Where does MM arise?
- bone marrow
- The 2 most common ab's, in order, are:
- IgG (55%), IgA (25%)
- Common multiple myeloma symptoms are:
- lytic bone lesions and hypercalcemia, renal insifficiency, increased suscpetibility to infection, anemia
- This disease is associated with:
- primary amyloidosis
- Ig light chains are also called:
- Bence Jones proteins
- 3 key diagnostic features:
- lytic bone lesions on x-ray, M-spike on serum protein electrophoresis, Bence-Jones proteins in urine
- Red blood cell appearance on peripheral smear:
- Rouleaux formation (poker chips)
- What 2 differences are seen in Waldenstrom's macroglobulinemia?
- M-spike is IgM, no lytic lesions