Leukocytes and Platelets
Terms
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- Leukocytes develope from ________________ in the_________
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Pluripotent stem cell
bone marrow - Sequence of maturation of granulocytes
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Myleblast
Promyelocyte
Myelocyte
Metamyelocyte
Band Neutrophil
Segmented neutrophil - Phagocytic system
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Neutrophils
Eosinophils - parasites
Macrophages (tissue only)
Less specific phagocytosis - Sequence of maturation of Agranulocytes
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Lymphocytes:
Lymphoblast
Proplymphocytes
Lymphocytes
Monocytes:
Monoblast
Promonocyte
Monocyte - Physiologic Leukocytosis
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Young, excited fearful animals
Mild neutrophilia wo left shift
Mild lymphocytosis
uncommon in k9, common in cats and horses
caused by stress - Stress Leukocytosis
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corticosteroid therapy
stress, pain, extreme change in temp.
neutrophilia wo left shift
lymphocytopenia
eosinopenia
+-monocytosis
more common in cats than dogs - Inflammatory Leukocytosis
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infections
neutrophilia w/ left shift
bacterial, protzoal, fungal and viral infections
degree of neutrophilia; localized pus has greater response than pyo - Non-Inflammatory leukocytosis
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Physiologic leukocytosis
stress leukocytosis - Neutrophilia
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inflammation
stress/corticosteroids
excitement
leukemia
bacterial infection - Neutropenia
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severe bacterial infection
viral infections
panleukopenia
K9 parvo
K9 hep
immunosuppresants
neoplasia - Lymphocytosis
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excitement
leukemia
lymphosarcoma
post vaccination
viral/bacterial infection - Lymphocytopenia
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stress/corticosteroids
acute systemic disease
immuno deficiency - Monocytosis
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chronic inflammation
stress/corticosteroids - Eosinophilia
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intestinal parasites
HW
hypersensitivity - Eosinopenia
- stress/corticosteroids
- Basophilia
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HW
allergic respiratory disorders
OCCURS with Eosinophilia - Neutrophils
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Phagocytic - engulf and destroy bacteria and other particles
survives up to 10 hrs in blood;1 day in tissues
cells more immature than myleocytes are unable to engulf partical matter - Lymphocytes - 2 types
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gut-associated - plasma cells
produce antibodies
thymic-associated - cellular immunity responsible for graft rejection and hypersenstivity reaction