Serotinin Agonists and Antagonists
Terms
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- 5HT has been implicated in these disease states:
- Depression, anxiety, schizo, eating disorders, OCD, migraines, and panic disorders
- What are the major stores of 5HT? (4)
- Enterochromaffin cells, platelets, CNS (raphe nuclei), pineal gland
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How many 5HT receptor families are there?
What are 5HT 1,2, & 4-7?
What is 5HT 3? - 7; Protein coupled. A 5HT gated ion channel
- About how many subtypes of each family are there?
- 14
- What is the fxn of the 5HT1 receptors?
- They inhibit the release of 5HT
- What is the fxn of 5HT2 receptors?
- Vasoconstriction, dilates the heart muscle, CNS action
- What is the fxn of the 5HT3 receptors?
- They are present in the CNS vomiting center
- This 5HT-1 (one) partial agonist treats anxiety and depression?
- Buspir-ONE
- This 5HT1D agonist is used to to "Ma's" graine (migraine)?
- Sumatriptan
- This 5HT2A/2C antagonist is used for migraines, depression, and schizo
- Ketanserin
- This 5HT3 antagonist is used in chemo and induced vomiting?
- ondansetron
- This 5HT4 agonist is effective in nighttime acid reflux?
- Cisapride
- This 5HT transporter acts as an inhibitor. It is a common tx for depression, and OCD
- Fluoxetine