ThrombosisRx

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actiated plateles accelerate the coagulation pathway or slow it down?: accelerate
the coag proteins like thrombin contribute to platelet aggregation T or F: True
list the events in order... a. aggregation b. platelet adhesion to the site of injury c. activation of platelet surface receptors and release of platelet products: b, c, a
GPIa/IIa to collagen and GPIb to von Willibrand factor describe which process? a. platelet adhesion to the site of injury b. activation of platelet surface receptors c. aggregation: a
ADP serotonin TXA2 are .. a. involved in activation of platelet surface receptors and release of platelet products b. aggregation c. platelet adhesion to the site of injury: a.
that receptor does thienopyridine block?: P2Y
aspirin blocks ... a. COX1 b. P2Y receptor c. your mom d. GPIIb/IIIa: a. cox 1
what is the moa of dipyridamole?: decrease cAMP
what is the mechanism of action of ASA (aspirin): irreversible acetylates cox1 and inhibits the conversion of arachidonic acid to thromboxane TXA2 in platelets
true of false: asa does not inhibit TXA2 synthesis and has tons and tons of effect on other factors that could initiate platelets activation and aggregation: false.
asa only inhibs TXA synthesis and has no effect on other factors that could initiate platelets activation and aggregtaion
what is an adverse effect of Aspirin: dyspepsia, nausea, gi bleed, hemorrhagic strokes, allergic rxn, asthma exacerbation and gout
name a thienopyridine: clopidogrel, prasugrel, ticopidine, ticagrelor
the primary indications of thienopyridines are... a. ACS, percutaneous coronary interventions, unstable angina, recent MI with or without ST-elevation b. CHF c. prostetic heart valves: a. ACS, percutenous coronary interventions, unstable angina, recent mi with or with out st elevation
what is a side effect of clopidogrel (other drugs in its class are prasurgrel, ticlopidine, ticagrelor): bleeding, dyspepsia diarrhea, neutropenia and thrombocytopenic purpura (with tilopidine)
what are two classes of inhibitors of GP IIB/IIIa: abciximab

tirofiban and eptifibatide
what drug, used in combo with warfarin, is used to inhibit formation of thromboemoli from prostetic valves?: dipyridamole
What dual antiplatelet therapy is the cornerstone of treatment to prevent thrombotic complications of ACS and PCI: aspirin and clopidogrel
what would be a good combination for triple anti platelet therapy. slide 14 10 am jan 25: asa, clopidogrel and eptifibatide, without anticoag therapy
what kind of drug do u incorporate to reduce major and minor adverse events in percutaneous coronary intervention that leads to decreased bleeding complications?`: eptifibatide based pharmacotherapy
anti coag drugs/anti thrombin drugs MOA: bind to antithrombin II and exposes its active site for more rapid inactivation of thrombin
what are the toxicities assc'd with heparin: bleeding allergy alopecia osteoperosis

heparin induced thrombocytopenia
if a patient has active bleeding and hemophilia intracranial hemorrhage or advance liver or renal disease should you give heparin?: no
what drug for a heparin OD: protamine sulfate
what are direct thrombin inhibitor drugs? a. hirudin and bivalirudin b. argatron and melagatran c. zyrtec c. propranolo: a and b
who are direct thrombin inhibitors mostly indicated for?: pts with HIT and venous thromboembolism
name two anticoagulant drugs that are orally effective: warfarin and coumarin
what is the MOA of warfarin and coumarin: Antagonize the vitamin K-dependent
gamma-carboxylation of glutamate resideus
in prothrombin, factors VII, IX, and X
as well as endogenous anti-coagulant
proteins C and S.
what are the toxicities of warfarin and coumarin: bleeding and many drug interactions

crosses placenta and causes birthdefects
what do u give to pts who OD or warfarin: vit K
streptokinase is... a. a antidepressant b. beta blocker c. fibrinolytic (thrombolytic) drug d. anticoagulant: c. fibrinolytic
what kinda drug is anistreplase?: fibrinolytic (streptokinase)
tissue plasminogen activators are a. anticoag drugs b. anti depressants c. ca channel blockers d. fibrinolytic ddrugs: d. fibrinolytic
which tissue plasminogen activator has a five min half life alteplasse, retaplase or tenecteplase?: alteplase
urokinase is... a. fibrinolytic b. thrombolytic c. ca channel blocker d. na channel blocker: a and b. its the same thing
what is the mechanism of fibrinolytic action: SK and tPA bind to plasminogen to release the serine
protease, plasmin, which in turn breaks apart the thrombus
(fibrin molecules).
what does excess plasmin protease do?: Excess plasmin protease can also cleave circulating fibrinogen
(fibrinogenlysis) and produces undesirable bleeding.
what is the diff between SK and tPA? tissue plasminogen activator and streptokinase: tPA is relatively selective for the clot-associated fibrin bound
plasminogen, rather than the circulating plasminogen, and hence
less likely to release a large amount of circulating plasmin and
causing systemic fibrinogenolysis.
what are some absolute contraindications of thrombolytic drugs: Suspected aortic dissection, active internal bleeding or uncontrollable external bleeding (excluding menses), recent head trauma (< 2 weeks), intracranial neoplasms, history of proven hemorrhagic stroke or cerebral infarction with 12 months, untreated diabetic hemorrhagic / proliferative retinopathy, uncontrolled BP (>180/110 mmHg), etc.
what does alpha-2 - antiplasmin do: inhibition of fbrinolysis
what does amicar (aminocaproic acid) do?: a lysine analog that compeetes for lys binding sites on plasminogen and plasmin thus blocking the interaction with plasmin with fibrin

inhibition of fibrinolysis
what are two inhibitors of tPA?: plasminogen activator 1 and 2
LO from the ITO discuss the principles and role of thrombosis in the pathogenesis of acute coronary syndrome (ACS): ... see ppt
ITO LO discuss the endogenous anti-thrombotic mechanisms and pathogenesis of coronary thrombosis: hope u know this
discuss the strategies and gasic pharmacology of the fibrinolytic drugs discuss the basic pharmacology of the anti-platelet drugs: this is a LO from the ITO

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Number of cards 44

Created By swimaline