Pharm II 2
Terms
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- Chlorpromazine - Thorazine
- Primarily D2 dopaminergic receptor site blockade
- Prochlorperazine - Compazine
- Primarily H1-histamine receptor antagonist
- Respiradone - Risperdal
- ?unknown, yet presumed to be dopamine and serotonin receptor blockade
- Haloperidol - Haldol
- D2 dopaminergic receptor site blockade
- Clozapine - Clozaril
- Mult. receptor site blockade, usu at D2 and S (serotonin) receptors
- Omeprazole - Prilosec
- H+/K+ -ATPase proton pump inhibitor
- Cimetadine (Tagamet)
- antagonist at H2 receptors
- Hyoscyamine (Anaspaz)
- cholinergic antagonist
- Sucralfate - Carafate
- aluminum sucrose polymerizes in acidic environments - (gives protective coating)
- Psyllium
- Bulk forming, swells in presence of water.
- Magnesium Hydroxide (Milk of Magnesia)
- Osmotic retention of fluid in colon
- Bisacodyl
- Stim. intestinal motility and accum. of electrolytes and water
- Dephenoxylate and Atropine (Lomotil)
-
D- opiod and alpha receptor agonist causing decreased motility and secretion
A- muscarinic antagonist that decreases motility and secretion - Loperamide - Imodium
- opioid and alpha receptor agonist causing decreased motility and secretion
- Apomorphine
- Stim. CRTZ
- Syrup of Ipecac
- Stim. CRTZ and local irritant in GI tract
- Ondanstetron - Zofran
- Serotonin antagonist - anti-emetic
- Diphenhydramine - Benadryl
- H1 receptor antagonist
- Alendronate
- Inhhibition of osteaoclast activity
- Raloxifene - Evista
- Selective Estrogen Receptor Modulator (SERM)
- Calcitonin
- inhibits osteoclastic activity
- Teriparatide
- inhibits osteocast activity (stim. new bone form)
- Hydrocortisone
- affects gene transcrip. to stim. or repress pro. tx
- Prednisone
- affects gene transcrip. to stim. or repress pro. tx
- Dexamethasone
- affects gene transcrip. to stim. or repress pro. tx
- Fludrocortisone
- Na+ retained and not lost
- Spironolactone
- aldosterone antag. by competitive binding (inhib. of Na+ retention)
- Glipizide
- Stim. release of insulin
- Metformin
- increase sensitivity to insulin in liver and elsewhere
- Acarbose
- enzymes inhib. alpha-glucosidase to slow digestion of carbs.
- Rosiglitazone
- increase sensitivity to insulin
- Repaglinide
- augments insulin release to meal response
- Glucagon
- agonist at glucagon receptors
- Leuprolide - Lupron
- Synthetic analog of GnRH - interrupts production of testosterone and estrogen
- Finasteride - Proscar
- Limits conversion of testosterone to DHT
- Premarin
- Alters gene transcrip. and supresses FSH
- Medroxyprogesterone - Provera
- Alters gene transcrip. and supresses LH
- Human Growth Hormone (Humatrope)
- Binds to GH receptor on cells (promoting formation of other hormones)
- Bromocryptine
- Dopamine agonist
- Vasopressin
- Stim. V1 receptors in smooth muscle and V2 receptors in collecting duct
- Oxytocin
- Stim. specific receptors in myometrium that cause direct m. contraction and prostaglandin release
- Levothyroxine - Synthroid
- Replaces normal levels of T4 and T3
- Thyroid USP - Armour
- Replaces both T4 and T3
- Methimazole
- Inhibits transformation of inorganic iodine to organic iodine - to block production of thyroxine.
- Propylthiouracil
- Blocks peripheral conversion of T4 to T3. Inihibits transformation of inorganic iodine to organic iodine - blocks production of thyroxine.
- Methysergide
- Unknown - mb peripheral serotonin antagonist and central serotonin agonist.
- Sumatriptan - Imitrex
- Serotonin Antagonist at 5 HT1D receptors, (that innvervate the intracranial vasculature.)
- Testosterone cypionate
- alters gene transcription. and at tissue level and increases pro. synthesis
- Insulin Lispro - Humalog
- binds to receptors to take in glucose