Respiratory Pharm
Terms
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Name one non selective B agonist
SE -
isopropterenol
tachycardia due to B1 - Name four B2 selective agonists
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metaproterenol
terbutaline
albuterol
salmeterol - Terbutaline use
-
status asthmaticus
(a condition where an asthma attack is refractory to initial bronchodilator therapy) -
Salmeterol use
SE (2) -
long acting B2 agonist used for
prophylaxis in asthma
tremor and arrhythmia -
Theophylline MOA (as well as caffiene)
Why is it a second line agent for asthma -
inhibits phosphosiesterase thus increases cAMP
(it also blocks adenosine receptors, which adenosine causes bronchconstriction and inhibits AV nodal conduction)
it mimics any Gs (nervousness, GI disturbances, arrhythmia) -
Ipatropium MOA
use (2) -
muscasinic antagonist
thus blocks bronchoconstriction (also mucus secretion)
asthma (though adrenergics are better)
COPD -
Cromolyn Sodium and Nedocromil MOA
(both administered by inhalation)
use -
inhibits mast cell degranulation
prevents asthma attacks (ineffective against acute asthma attacks) -
Prednisone use
SE (4) -
severe chronic and acute attacks
osteoporosis
hyperglycemia
dysphoria/psychosis
immune suppression -
Beclemethasone:
(1st line for chronic asthma)
what is imp about it
MOA
SE -
inhaled agent does not get into systemic
inhibits NFkB which decreases TNFa
also decreases release of virtually all cytokines
hoarseness - Zileuton MOA
- 5 lipooxygenase inhibitor
- Zafirlukast MOA
- blocks leukotriene receptors (LTD4)