pharm-anti-neoplastic
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- Cyclosporine
- 80. Protects against rejections from organ transplants 81. Does not induce bone marrow depression
- Cyclophosphamide
- 82. Alkylating agent of both purine & pyrimidine bases of DNA 83. Txt CLL
- CisplatinÂ’s toxicities
- 84. Nephro- & Ototoxicity
- Methotrexate
- 104. Folic acid analog that (-) tetrahydrofolate synthesis by (-) dihydrofolate reductase 105. Txt of ALL 106. Txt of Psoriasis
- Leucovorin Rescue
- 86. Can block/reduce Methotrexate = inc. folic acid via a reduced folate
- Bleomycin toxicities
- 87. Pneumonitis & pulmonary fibrosis
- Azathiorine
- 88. Used in organ transplantation = kidney allografts 89. Allopurinol can inc. its activity by (-) its biotransformation to xanthine oxidase
- MOPP
- 90. Chemotherapy used in the txt of Hodgkin ‘s disease 91. M = Mechlorethamine – nitrogen mustard 92. O = Oncovin (Vincristine) – prevents microtubule assembly 93. P = Procarbazine 94. P = Prednisone – glucocorticoid, inducing apoptosis
- Tamoxifen
- 95. (-) estrogen receptor 96. Txt of breast tumors, can see associated endometrial CA
- Flutamide
- 97. Antiandrogenic 98. Used w/ Leuprolide (LH-RH analog) 99. Txt prostatic CA
- Megestrol
- 100. (-) progesterone receptor 101. Txt endometrial CA
- Fluoxymesterone
- 102. Androgenic steroid 103. Txt mammary CA in postmenopausal women
- Brain tumor Txt
- 107. Lomustine 108. Carmustine – Causes pulmonary fibrosis
- Streptozocin
- 109. Attaches to â cells 110. Txt of pancreatic insulinomas
- Cytarabine (AraC)
- 111. Pyrimidine analog 112. DOC for AML
- Dactinomycin
- 113. Used for Wilms tumor & rhabdomyosarcoma
- Etoposide
- 114. Used for oat cell CA
- Paclitaxel
- 115. Used for ovarian CA
- Amifostine
- 116. Can dec. nephrotoxicity due to chronic use of Cisplatin