pharm-anti-infective
Terms
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- Primaquine
- 4. Malaria profylaxis 5. Used for extraerythrocytic forms Plasmodium vivax or P. ovale Ciporfloxacin 6. Quinolone derivative
- Sulfonamides
- 7. PABA structural analogs 8. Inhibit Folic acid synthesis
- Tertacyclines, anuria & the exception
- 9. Should not be used in anuric pt due to production of (-) Nitrogen balance & inc.d BUN levels. 10. Doxycycline is the exception
- Ceftriazone
- 11. 3rd generation cephalosporin 12. DOC for bacterial meningitis in kids (ieÂ… HiB) 13. One dose txt of gonorrhea
- Hepatic coma DOC
- 14. Neomycin (aminoglycoside) – it supresses the normal flora = dec.g NH4 production = dec.g free nitrogen levels in the bloodstream.
- Clavulanic acid
- 15. Irreversible (-)r of â lactamases, but ot of transpeptidase = use w/ a â lactamase sensitive penicillin
- Piperacillin
- 16. Txt Pseudomonas aeruginosa & Klebsiella 17. Broad spectrum antibiotic
- Streptomycin (aminoglycoside)
- 18. Txt Mycobacterium tuberculosis
- Isoniazid
- 19. Most commonly used drug for TB. 20. Usually combined w/ Rifampin and/or Ethambutol 21. Pre Txt w/ Pyridoxine (Vit B6) can prevent peripheral neuritis‘
- Pyrantel Pamoate
- 22. Txt of Hookworm disease23. Depolarizing NMJ (-)r
- Buy “AT” 30, “CELL” at 50
- 24. A = Aminoglycosides 25. T = Tetracyclines 26. C = Chloramphenicol 27. E = Erythromycin (macrolide) 28. L = Clindamycin 29. L = Lincomycin
- Cefoxitin
- 30. Txt intraabdominal infections (ieÂ… w/ Bacteroides fragilis) 31. Traditional txt has been Clindamycin & Gentamycin
- Chloramphenicol
- 32. Broad spectrum antibiotic 33. Bone marrow depression (common) – Aplastic anemia (rare) 34. Gray baby syndrome (chloramphenicol cannot be conjugated) 35. DOC Typhoid Fever (symptomatic Salmonella infection) 36. DOC HiB meningitis in kids – especially resistant strain to ampicillin
- Nifurtimox
- 58. DOC Chagas disease due to Trypanosoma cruzi
- Metronidazole 3
- 8. Txt Leishmaniasis & Amebiasis 39. Good for anaerobic bacteria = Bacteroides fragilis 40. DOC Trichomoniasis 41. DOC Giardia lamblia
- Txt P. carinii
- 42. TMP-SMX & Pentamidine
- Tetracycline
- 43. Txt of Brucellosis & Cholera 44. Txt Rocky Mountain Spotted Fever 45. Txt spirochete infections = Lyme disease (Borrelia burgdorferi)
- TMP-SMX
- 46. (-) dihydrofolate reductase activity
- Benzathine Penicillin G
- 47. Long duration of action = given once every 3-4 weeks for Txt of Syphilis
- Praziquantel
- 48. Txt Schistosomiasis (trematode [fluke] infections)
- Melarsoprol
- 49. Txt Trypanosomiasis that has neurological symptoms
- Stibogluconate
- 50. Txt Leishmaniasis
- Fluconazole
- 51. Txt fungal encephalitis
- Amphotericin B
- 52. Polyene antifingal
- Ketoconazole MOA
- 53. (-) fungal ergosterol synthesis = disrupts membrane
- Griseofulvin MOA
- 54. Accumulates in keratinized layers of the skin = used in dermatomycoses infections
- Mefloquine
- 55. Anti malarial 56. Txt Chloroquine resistant strains = P. falciparum
- Chloroquine
- 57. Txt for Malaria when inside RBC
- Erythromycin
- 59. Used in pts allergic to penicillins
- Nystatin
- 60. Topical txt of superficial mycotic infections = Candidiasis
- Acyclovir
- 61. Guanine analog 62. Txt Herpes infections
- Imipenem
- 63. Used w/ Cilastatin 64. Can cause seizures
- Cefoperazone side effects
- 65. Bleeding due to vit K level alterations 66. Contraindicated in pts w/ bleeding disorders
- Vancomycin
- 67. Used for MRSS (methicillin resistant Staph. Aureus) 68. “Red neck”: due to histamine release causes facial flushing
- Meropenem
- 69. used w/ Cilastatin 70. Does not cause seizures (cf w/ Imipenem)
- Nafcillin
- 71. Only penicillin that does not need dose adjustment in renal impairment
- Peripheral neuropathy
- 72. Seen w/ use of: 73. Metronidazole – Isoniazid – Vincristine – ddI – AZT – Allopurinol
- Sulfonamides & newborns
- 74. Kernicterus can occur
- “O.N.E.” for gonorrhea
- 75. Fluoroquinolones used in a one dose deal for gonorrhea: 76. O = Ofloxacin 77. N = Norfloxacin78. E = Enoxacin
- Ribavirin
- 79. Txt RSV (Respiratory Syncytial Virus)