pharm-ans
Terms
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- Epinephrine
- 1. á1, á2, â1, â2
- Norepinephrine
- 2. á1, á2, â1 (no â2 activity)
- GABA
- 3. Causes an inhibitory cell hyperpolarization
- Muscarinic-r
- 4. Uses DAG & IP3 as 2nd messengers 5. Parasympathetic control
- Bethanechol
- 6. Cholinergic. inc. GI & Bladder motility. Txt atonic bladder post-op
- Pilocarpine
- 7. Cholinergic. Pupillary constriciton= miosis. Ciliary constriction= accomodation. 8. Txt acute glaucoma
- Isoflurophate
- 9. Organophosphate. Irreversible acetylcholinesterase (-)r
- Pralidoxime
- 10. “2PAM”. Reverses organophosphate binding to acetylcholinesterase
- Neostigmine
- 11. Reversible acetylcholinesterase (-)r 12. Txt Myasthenia Gravis
- Tubocurium
- 14. Nondepol. Competitive cholinergic N-r (-)r. 15. Prevents Ach binding but does not activate NMJ 16. inc. Histamine release= dec. BP & inc. bronchospasm
- Trimethaphan
- 17. Nonselectively binds N-r of the PS- and SNS
- Pancurium
- 18. More potent than tubocurium w/o histamine release
- Succinylcholine
- 19. Depol. Non competitive (-)r of muscle action 20. Opens Na Ch.= fasciculations. Closes Na Ch.= paralysis. Continuous infusion.
- á1 & Eye
- 37. Contracts radial muscle = mydriasis (pupil dilation)
- M-r & Eye
- 22. Miosis due to Ach. Atropine (-).
- Sympathetic
- 23. Post ganglionic symapthetic fibers releases norepinephrine
- Parasym.
- 24. Post ganglionic parasympathetic fibers release Ach
- M3-r & Eye
- 25. Contracts sphincter = miosis. Contracts ciliary = accomodation.
- M2-r & Heart
- 26. Negative chronotropy: dec. HR = vagal arrest 27. Negative inotropy: dec. contractility
- M3-r & Lung
- 28. Bronchospasm inc.secretions
- M3-r & GI
- 29. inc. motility (cramps & diarrhea). Involuntary defecation
- Tacrine 3
- 0. Acetylcholine esterase (-)r. Txt Alzheimer ‘s
- Atropine
- 31. DOC w/ vagal arrest
- Glycoperrolate
- 32. M-r(-). Antispasmodic. Txt peptic ulcers.
- Pirenzepine
- 33. M-r(-). Antispasmodic. Txt peptic ulcers.
- Doxacurium
- 34. Most potent competitive non-depol NMJ (-)r. No cardiovascular side effects. No Histamine release.
- á bungarotoxin
- 36. Irreversible N-r (-)r = dec. action potentials
- á1 & Arterioles
- 38. Constiction: inc.TPR = inc. Diastolic pressure = inc. Afterload
- á1 & Venules
- 39. Constriction: inc. Venous return = inc. Preload
- á1 & Sex Function
- 40. Ejaculation
- inc. Diastolic
- 41. inc. á1 = inc.TPR
- dec. Diastolic
- 42. inc. â2; Direct acting vasodilators; (+)Cholinergics
- â1 & Heart
- 43. (+)chronotropism = inc.HR. 44. (+)inotropism = inc. contractility; inc.SV; inc.CO; inc.O2 consumption. 45. inc. conduction velocity
- Phenylephrine
- 46. á1 (+) Nasal decongestant.
- â2(+) Asma Drugs
- 47. Metaproterenol; Albuterol; Terbutaline; Ritodrine; Salmeterol
- Ritodrine/Turbutaline
- 48. Relaxes myometrium used in pre-mature labor pains
- Phentolamine
- 9. Epi reversal. Blocks á, vasodilation occurs. Pt goes from HyperTN to HypoTN. 50. Txt pheochromocytoma = dec.BP
- Terazosin
- 51. Txt BPH
- Yohimbine
- 52. inc. sympathetic outflow = á2 (-). Txt impotence.
- Cardioselective NMJ
- 53. Pancuronium = inc.HR due to atropine-like anti muscarinic vagolytic effect & Gallamine (-)r
- Ecothiophate
- 54. Irreversible cholinesterase (-)r.
- Pyridostigmine
- 55. Cholinomimetic that inc.s M & N-r effects. (-) acetylcholinesterase & plasma cholinesterase 56. DOC for the oral Txt of MG