sulfonamides 11/10/06
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- sulfonamides MOA
- 1) PABA analog - inhibit DHPS (dihydropteroate synthase) which is required for folic acid synthesis
- sulfonamides are considered to be?
- bacteriostatic
- sulfonamides may displace?
- bilirubin from plasma albumin binding sites
- so, it causes ??? in neonates
- Kernicterus
- sulfonamides may be antagonized by?
- local anesthetics that are esters of PABA (Procaine)
- adverse effects of sulfonamides?
-
1) hypersensitivity
2) photosensitivity
3) Stevens-Johnson syndrome
4) crystalluria
5) hemolytic anemia
6) N/V, diarrhea
7) hepatic necrosis
8) blood dyscrasias - sulfonamides are DOC for?
- nothing
- sulfonamides are alternate drugs for?
-
1) Chlamydia trachomatis
2) Nocardia
3) some UTIs (Bactrim)
4) some N. meningitidis - Sulfisoxazole (Gantrisin) with phenazopyridine
- Azogantrisin
- Sulfisoxazone + Erythromycin ethylsuccinate =
- Pediazole
- Sulfamethoxazole (Gantanol) + Trimethoprim =
- Bactrim, Septra (for UTI)
- Silver Sulfadiazine =
- Silvadine (DOC for prevention of burn infe.)
- Sulfadoxine + Pyrimethamine =
- Fansidar (for chloroquine-resistant malaria)
- Sulfacetamide (Sulamyd, Isoptocetamide) + sulfur =
- Sulfacet-R-lotion for acne
- Mafenide (Sulfamylon) for
- to prevent burn infe.
- Trimethoprim-Sulfamethoxazole (Bactrim, Septra) is DOC for?
-
1) acute UTI
2) Nocardia
3) Moraxella catarrhalis
4) H. flu
5) Yersinia enterocolitica