ICS-Heme-Spleen
Terms
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- fxn of spleen
-
1. protect against blood borne (not interstitial) pathogens
2. specific immune responses
3. production adn processing of opsonins (tufsin and properdin) - Et of splenomegaly
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1. Congestive (CHF, cirrhosis, thrombosis)
2. Infxn
3. Inflamm
4. Sequestration of RBC
5. Infiltrative, non-malignant
6. Maligancies (leukemias, lymphomas) - lab results in pts with splenomegaly
-
-invading organisms
-toxic granulations, Dohle bodies, vacuoles in neutrophils
- - fragmented erythrocytes
- overwhelming sepsis
- nucleated red cells + tear-drop shaped cells
- BM invasion
- immature white cells or blasts in periph blood smear
- hematologic malignancy
- most imp cause of functional hyposplenism
- sickle cell
- what are Howell Jolly bodies
- RBC inclusions on peripoheral smear
- loss of immunologic fxn due to asplenia/hyposplenia can lead to what?
- DEATH!
- result of asplenia/hyposplenia
- DEATH! due to overwhelming infxn: **Streo pneumo, H flu, N. men
- Sx of asplenia//hyposplenia
- fever, then rapidly evolves into septic shock (and DIC possibly)
- what can you do to prevent overwhelming infxn post-splenectomy?
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Antibiotic Chemoprophylaxis:
DOC=penicillin/amoxacillin - lab results of splenomegaly
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-toxic granulations
-Dohle bodies
-vacuoles in neutrophils - hypersplenism
- splenomegaly + destruction of 1 or more ell lines in periph blood