USMLE Step 2 - Neurology
Terms
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-
Parkinson's Disease -
What is it
When does it start
Life expectancy -
ACh and dopamine must be
in balance for normal,
balanced movement
dec. levels of dopamine
in substantia nigra
idiopathic hypokinetic
usu. starts ~50-60 y/o
life expectancy ~ 9 yrs. -
Parkinson's Disease -
Insults that lead to
"parkinsonism" -
Most cases are idiopathic
insults dec. dopamine -
postencephalitic
toxic insults -
(carbon disulfide
manganese
MPTP)
bihemispheric ischemic
traumatic
iatrogenic (neuroleptic meds) -
Parkinson's Disease -
History/PE -
Tremor at rest (pill rolling)
cogwheel rigidity
bradykinesia
festinating gait
stooped posture
unstable posture
masked facies
memory loss
micrographia
shy-dragger-
any autonomic dysfunction -
Parkinson's Disease -
Tx -
1st -
is it from a secondary cause
that can be reversed?
then -
how does pt. function daily?
tremor but functioning -
> 60 y/o - amantidine
< 60 y/o - anticholinergic
if can't function -
l-dopa-carbidopa
most effective
but most side effects
"response fluctuations"
Tx fluctuations -
COMT or selegiline
list of meds -
L-dopa/carbidopa - mainstay
bromocriptine
selegiline
entacapone (COMT inhib)
amantadine & anticholinerg -
limited efficacy
If meds fail & dis. advanced-
deep brain stimulation of
GPi and subthal nucleus,
or pallidotomy -
ablation of GPi
(posteroventral GP)
rarely done now -
Huntington's -
What is it -
Hyperkinetic
AD
atrophy of caudate
lose GABA
CAG triple repeats on C4p
anticipation -
prog. expansion
> 39 repeats - mutant genes -
Huntington's -
History/PE -
Presents ~30-50 y/o
gradual onset of -
chorea
dementia
altered behavior
depression -
Huntington's -
Dx -
Clinical
CT
MRI
molecular genetic testing -
Huntington's -
Tx -
No cure
disease cannot be halted
genetic counseling
haloperidol - psychosis
reserpine -
minimize unwanted movements -
Alzheimer's -
What is it -
MCC of dementia in elderly
⬢ senile plaques - B amyloid
⬢ neurofibrillary tangles -
abnorm phosphorylated tau protein
⬢ loss of ACh in cortex -
basal nucleus of Meynert
⬢ amyloid angiopathy
=> lg lobar hemorrhage
⬢ hippocampus affected early -
Alzheimer's -
Risk factors -
Age - most important
family history
Down's (> 35 y/o)
female gender
chromosomes 21, 14
chromosome 1 - younger age
chromosome 19 - older
homozygous for ApoE4 -
high rate of Alzheimer's -
Alzheimer's -
History/PE -
Amnesia usually 1st sign
then language deficits
acalculia
depression
agitation
apraxia -
Alzheimer's -
Evaluation -
Dx of exclusion
def. Dx only on autopsy
MRI or CT -
diffuse cortical
and subcortical atrophy
Neuropsych testing -
distinguish between
dementia and depression -
Alzheimer's -
Tx -
Supportive therapy
Cholinesterase inhibitors -
first-line therapy
donepezil
rivastigmine
galantamine
Vit E (a-tocopherol) -
may slow cognitive decline -
Alzheimer's -
Complications -
Survival is 5-10 yrs from
onset of sxs
death usually secondary to
aspiration pneumonia or
other infections -
Delirium -
What is it caused by
Timing of onset
Course -
Caused by acute illness,
infection or drug toxicity
Sudden onset
Reversible (usually)
impairment of consciousness -
dec. awareness of your envi
can't maintain attention -
Dementia -
What is it caused by
Timing of onset
Course -
Caused by anatomic changes
in the brain
Slow, gradual onset
Irreversible -
Subarachnoid Hemorrhage -
What is it -
Due to bleeding
from ruptured aneurysm
MCC - head trauma
(Circle of Willis)
(considered separate d/o)
spontan - ruptured aneurysm
usually congenital berry
associated with APKD,
coarctation of aorta
other cause - AV malformation
~50-60 y/o
high mortality -
Subarachnoid Hemorrhage -
History/PE -
Sudden-onset headache
"worst headache of my life"
loss of consciousness
fever
n/v
neck stiffness
seizure
CN3 palsy - if berry aneurysm
may be preceded by
milder sentinel headaches
weeks earlier -
Subarachnoid Hemorrhage -
Dx -
CT without contrast immed.
blood appears white
if CT neg -
LP immediately
ck for xanthochromia
no LP if inc. ICP -
sudden dec. in CSF pressure
can cause further bleeding
4-vessel angiography
to pinpoint location -
Subarachnoid Hemorrhage -
Tx -
Prevent 2nd rupture -
most likely in 1st 48 hrs
obliterate aneurysm
IV fluids
keep BP OK
nimodipine -prevent vasospasm
phenytoin
lower ICP -
raise head of bed,
hyperventilation
pain meds - no NSAIDs
surgery -
clip aneurysm
IR (stent-assisted) coiling -
Subarachnoid Hemorrhage -
Complications -
2nd rupture -
esp. with aneurysm
extend into brain parenchyma-
esp. with AVM
arterial vasospasm
obstructive hydrocephalus -
Epidural Hematoma -
What is it -
Often due to blunt trauma
usually lateral skull fracture
tear of Middle Meningeal Art. -
Epidural Hematoma -
History/PE -
Lucid interval - min. to hrs.
then headache
progressive obtundation
hemiparesis
"blown pupil" -
Epidural Hematoma -
Dx -
CT -
lens-shaped
convex hyperdensity
close observation and
serial neuro exams
before surgery -
Epidural Hematoma -
Tx - Neurosurgical evacuation
-
Subdural Hematoma -
What is it -
Usually after head trauma
rupture of bridging veins
cortex to dural sinuses
esp. elderly & alcoholics -
Subdural Hematoma -
History/PE -
Headache
change in mental status -
days to weeks
can present as dementia
in elderly
contralateral hemiparesis
may have remote h/o fall -
Subdural Hematoma -
Dx -
CT -
crescent-shaped
concave hyperdensity -
Subdural Hematoma -
Tx -
Neurosurgical evacuation
blood may regress spontan-
eously if chronic
corticosteroids
phenytoin -
Parenchymal Hemorrhage -
Causes -
HTN (usually in basal ganglia)
tumor
amyloid angiopathy - elderly
vascular malformations -
AVM
cavernous hemangiomas -
Parenchymal Hemorrhage -
History/PE -
lethargy
headache
focal mtr & sensory deficits
some obtundation -
Parenchymal Hemorrhage -
Dx -
CT without contrast
check for mass effect
or edema -
Parenchymal Hemorrhage -
Tx -
Raise head of bed
antiseizure prophylaxis
neurosurgical evacuation -
if mass effect
esp. in posterior fossa -
Coma -
What is Rule of 4 -
1. Thiamine, D50, naloxone
coma cocktail
2. 2 mechanisms
bilateral hemisphere or
RAS
3. 3 general dis. processes
structural
metabolism
seizures
4. 4 key aspects to exam -
Coma -
General Processes: Structural -
Hematoma
Infarction
Abscess
Tumor
Abnormal imaging lesion
that occupies space -
Coma -
General Processes: Metabolism -
Electrolyte, endocrine or
metabolic functions
substrate deprivation -
O2, glucose
vitamin deficiency
organ failure - kidney
toxins -
meds
etoh
drugs
infections
inflammatory dis.
Normal imaging -
Coma -
General Processes: Seizures -
Status epilepticus
postictal -
Coma -
4 aspects of exam -
Pupils
eye movement
motor response
ventilation pattern -
acid-base status -
Coma -
Tx -
Stabilize the patient -
Airway
Breathing
Circulation
Reverse the reversible -
coma cocktail
O2
ID and tx underlying cause
Prevent further damage -
Broca's Aphasia -
What is it
What part of brain affected -
D/o of language production
motor
broken speech
comprehension is intact
expressive or
nonfluent aphasia
post. inferior frontal gyrus -
Broca's Aphasia -
Features -
Repetition is impaired
frustration - cuz aware
associated with -
arm and face hemiparesis
hemisensory loss
apraxis of oral muscles
often secondary to
left superior MCA stroke -
Broca's Aphasia -
Tx -
Speech therapy
tx underlying condition
wide range of outcomes
intermediate prognosis -
Wernicke's Aphasia -
What is it -
D/o of language comprehension
nonsensical production
Wernicke's is wordy
left post. superior temporal
receptive or fluent aphasia -
Wernicke's Aphasia -
Features -
Neologisms
word substitutions
unaware - no comprehension
secondary to
left inf./post MCA stroke -
Wernicke's Aphasia -
Tx -
Speech therapy
tx underlying condition
poorer prognosis than Broca's -
Brain Neoplasms -
Mets vs. Primary -
Benign usually > 65 y/o
Metas -
Lots of Bad Stuff Kills Glia
Lung Breast Skin Kidney GI
metas > primary
supratentorial
at junction of gray and
white matter
Primary (1o) -
MC primary in adults -
glioblastoma and meningioma
most 1o are supratentorial
MC primary in kids -
medulloblastoma & astrocytoma
most 1o are infratentorial -
Brain Neoplasms -
Dx -
CT with contrast
MRI with gadolinium
CT-guided Bx
Bx during surgical tumor
debulking -
Brain Neoplasms -
General Principles of Tx -
Resection (if possible)
radiation
chemo
palliative tx
corticosteroids -
reduce vasogenic edema
type of therapy depends on -
type of tumor
histology
progression
site -
Brain Neoplasms:
Glioblastoma -
Characteristics and
Presentation -
Grade IV astrocytoma
MC primary brain tumor
prognosis grave
< 1 year to live
can cross corpus callosum
progresses fast
headache
ICP -
Brain Neoplasms:
Glioblastoma -
Tx -
Surgical resection
radiation and chemo
have variable results -
Brain Neoplasms:
Meningioma -
Characteristics and
Presentation -
2nd MC primary
often incites osteoblastic
reaction in overlying
cranial bones
orig from dura or arachnoid
good prognosis
incidence inc. with age -
Brain Neoplasms:
Meningioma -
Tx -
Surgical resection
radiation for unresectable -
Brain Neoplasms:
Acoustic Neuroma (Schwannoma)
Characteristics and
Presentation -
Derived from schwann cells
bilat schwannoma in NF2
Ipsilateral hearing loss
tinnitus
vertigo
signs of cerebellar dysfunction
facial weakness
facial sensory loss -
Brain Neoplasms:
Acoustic Neuroma (Schwannoma)
Tx - Surgical removal
-
Brain Neoplasms:
Astrocytoma -
Characteristics and
Presentation -
Grades 1 - pilocytic,
mainly kids
grade 2 - diffuse
grade 3 - anaplastic
grade 4 - glioblastoma multif
headache
inc. ICP
can cause unilat paralysis in
CN 5-7 & CN10 -
Brain Neoplasms:
Astrocytoma -
Tx -
Resection if possible
radiation -
Brain Neoplasms:
Medulloblastoma -
Characteristics and
Presentation -
Highly malignant
arises from cerebellum
and 4th ventricle
can compress 4th ventricle
may seed subarachnoid space
inc. ICP
morning headaches -
Brain Neoplasms:
Medulloblastoma -
Tx -
Surgical resection
coupled with
radiation and chemo -
Brain Neoplasms:
Ependymoma -
Characteristics and
Presentation -
Common in kids
arises from ventricles
and spinal cord
commonly found in 4th ventricle
can cause hydrocephalus -
Brain Neoplasms:
Ependymoma -
Tx -
Surgical resection
radiation -
Neurofibromatoses -
What are they -
NF1 -
von Recklinghausen
AD
chromosome 17
NF2
chromosome 22 -
Neurofibromatoses -
Hx/PE -
NF1 -
2 or more of:
neurofibromas (2)
cafe-au-lait spots (6)
freckling -
axillary or inguinal
optic glioma
lisch nodules (2)
osseous abnorm
1st degree relative with NF1
NF2 -
bilat acoustic neuromas
or
1st deg. relative with NF2
and unilat acoustic neuroma
or
1st deg. relative with NF2
and neurofibroma,
meningioma,
glioma
or schwannoma -
Neurofibromatoses -
Dx -
MRI -
brain
brain stem
spine
derm exam
ophthal exam
family Hx
hearing test -
Neurofibromatoses -
Tx -
No cure
tx symptoms
surgical removal for
acoustic neuromas -
Tuberous Sclerosis -
What is it -
Seizures - start as infant
mental retardation
skin and eye lesions
small benign tumors -
brain
face
eyes
kidney
other organs
very variable clinical course
AD
chromosome 9 -
Tuberous Sclerosis -
Hx/PE -
Infantile spasms
ashleaf lesions -
hypopigmentation
trunk and extremities
shagreen patch - lumbosacral
sebac. adenoma - nose, cheeks
mulberry tumors
phakomas -
Tuberous Sclerosis -
Dx -
CT -
calcified tubers
periventricular areas
can => astrocytomas (rare)
Wood's UV lamp - skin lesions
EKG
renal US -
Tuberous Sclerosis -
Tx -
Clonazepam or valproic acid
inc. ICP -
may indicate
a tuber obstructing
Foramen of Munro
surgery -
Von Hippel-Lindau -
What is it -
AD
deletion of VHL gene on ch 3
hemangioblastoma -
cerebellum
medulla
retinal angioma
RCC
pheochromocytoma -
Von Hippel-Lindau -
Hx/PE -
Headache
N/V
cerebellar Sxs
retinal angiomas -
usu. periphery
can => retinal detachment -
Von Hippel-Lindau -
Dx -
CT - head, abdo
MRI -
post. fossa emphasis
serpentine signal voids
angiography - vascularity
CBC - polycythemia
VMA levels in urine
ophthal US -
Von Hippel-Lindau -
Tx -
Surgical resection
or
radiation -
Osler-Weber-Rendu -
What is it -
AD
also called -
Hereditary Hemorrhagic
Telangiectasia (HHT)
telangiectasia and AVM
in lungs, GI, brain
recurrent epistaxis -
Osler-Weber-Rendu -
Hx/PE -
Recurrent epistaxis
painless bleeding in bowel
hepatic AV fistula -
(hepatomegaly
RUQ pain
pulsatile mass
palpable thrill
audible bruit
high-output CHF
liver failure)
hep. enceph - portosys shunt
neuro complications
rt-to-left shunt -
(cyanosis
clubbing
hypoxemia
2ndary polycythemia
exertional dyspnea) -
Osler-Weber-Rendu -
Tx -
Iron
folate
symptomatic tx of epistaxis
ASA - contraindicated
embolization,
surgical excision
or ligation of AV fistulas -
Closed-Angle Glaucoma -
What is it -
Med emergency
usu older pts. and Asians
iris root plugs opening of
trabecular meshwork
acutely
pupillary dilation
anterior uveitis
dislocation of lens -
Closed-Angle Glaucoma -
Hx/PE -
Intraocular pressure inc.
very fast
extreme periocular pain
acute red eye
blurred vision -
Closed-Angle Glaucoma -
Dx
Tx -
Best diagnostic test -
tonometry
Tx -
acetazolamide
pilocarpine - when P drops
laser iridotomy - curative -
Open-Angle Glaucoma -
What is it -
Most common form
almost always bilateral
risk factors -
> 40 y/o
Black
diabetic
myopic
family Hx
diseased trabecular meshwork
obstructs proper drainage
=> intraoc P inc. gradually
progressive vision loss
vision loss -
moves periph to central
=> blindness -
Open-Angle Glaucoma -
Hx/PE -
Asymp initially
suspect if pt. -
> 35 y/o
freq. lens changes
mild headaches
vision disturbances
impaired adaptation to dark
earliest defect -
periph nasal fields
cupping of optic disk -
Open-Angle Glaucoma -
Dx -
Tonometry
ophthalmic exam of optic n.
central field testing
eval on long-term basis
can be hard to Dx until
advanced stages -
Open-Angle Glaucoma -
Tx -
Prevention
> 40 y/o - exam every 3-5 yrs
inc. risk factor - annually
timolol, betaxolol
pilocarpine
acetazolamide
laser trabeculoplasty -
if meds fail -
Macular Degeneration -
What is it -
MCC of permanent bilat
vision loss in elderly
vision loss - central
do not lose periph
atrophic - gradual loss
exudative -
faster
damage more severe -
Macular Degeneration -
Hx/PE -
painless loss of
central vision
atrophic -
irreg pigmentation of
macular region
exudative -
hyperpigmentation
pimple-like elevation of
macula - from hemorrhage -
Macular Degeneration -
Tx -
Laser photocoagulation -
may delay loss of central
vision in exudative -
Retinal Artery Occlusion -
What is it
Hx/PE -
From emboli or thrombi
sudden
painless
unilat blindness
pupil accommodates but reacts
sluggishly to direct light
cherry-red spot on fovea
artery may look bloodless
retinal edema -
Retinal Artery Occlusion -
Tx -
Thrombolysis within
8 hrs of onset of Sx
dec. intraoc P -
drain ant. chamber
IV acetazolamide -
Retinal Vein Occlusion -
What is it
Hx/PE -
Sudden
painless
retinal hemorrhages
cotton wool spots
edema of fundus
elderly
MCC - HTN
can => macular dis., glaucoma -
Retinal Vein Occlusion -
Tx - Laser photocoagulation
-
Inc. ICP -
Causes -
Blood -
EDH, SDH, SAH, ICH
spontaneous or traumatic
CSF -
hydrocephalus
idiopathic intracranial HTN
brain mass -
tumor
trauma -cerebral contusions
edema -
trauma
tumors -
Inc. ICP -
Signs in approx. order
of appearance -
N/V and headache
altered mental status
in kids - bulging fontanelles
papilledema
CN palsies - esp. CN6
Cushing's Triad -
(HTN
brady
irreg breathing)
endstage -
cerebral herniation -
Inc. ICP -
Tx -
in order -
Make sure BP and resp. good
sedation
elevate head of bed
IV mannitol
hyperventilate to CO2 30-35
ventriculostomy
surgery -
removal of hematoma
decompressive craniectomy -
Herniation -
What is it
Types
Dx -
Endpoint of untreated masses
or inc. ICP
specific signs and Sxs
depends on type of hernia
and mass lesion
uncal herniation -
CN3 compression:
ipsilat dilated pupil
midbrain compression:
ipsilat hemiplegia
tonsillar herniation -
resp. compromise
Dx -
CT without contrast -
r/o mass lesion or hemorrhage -
Guillain-Barre -
What is it -
Acute
rapidly progressive
acq. demyelinating autoimmune
d/o of periph nerves
recent C. jejuni infection
viral infection
recent vaccination -
Guillain-Barre -
Hx/PE -
Rapidly progressive
ascending paralysis
involves trunk, diaph and CN
autonomic Sxs
areflexia -
Guillain-Barre -
Dx -
Diffuse demyelination on -
EMG & nerve conduction studies
albuminocytologic dissociation
CSF prot. > 55 mg/dL -
Guillain-Barre -
Tx -
ICU -
risk of respiratory failure
plasmapheresis or IVIG
aggressive rehab -
MS -
What is it -
Acq. demyelinating dis.
may have T cell-mediated
autoimmune pathogenesis
environmental and genetic
female-to-male 2:1
20-40 y/o
inc. prev. with gtr distance
from equator
risk - related to where lived
the 1st 15 yrs. of life
subtypes -
benign
relapsing/remitting
2o progressive
chronic progressive -
MS -
Hx/PE -
Mult. neuro complaints
sep. in time and space
can't be explained by a
single lesion
limb weakness
optic neuritis
paresthesias
diplopia
internuclear ophthalmoplegia
urinary retention
vertigo
Sxs wax & wane or progress
exacerbations -
stress
infections
heat
trauma
vigorous activity -
MS -
Dx -
Multiple, asymmetric periven-
tricular lesions in white mtr
corpus callosum lesions -
pathognomonic
active lesions enhance with
Gado on MRI
inc. CSF IgG
oligoclonal bands -
MS -
Tx -
Acute - steroids
treat Sxs -
spasticity: baclofen or zanaflex
pain: phenytoin
fatigue: amantadine or provigil
depression
avoid hot climates
prophylaxis:
immunomodulators
reduce no. of attacks, disability
Avonex - once wkly IM
Betaseron- every other day subq
Copaxone - daily subq -
Stroke -
Types -
Ischemic - 80%
emboli
thrombi
systemic hypoperfusion
hemorrhagic -
Stroke -
Risk Factors -
Age
male
race
HTN
diabetes
obesity
smoking
hypercholesterolemia
AF
carotid stenosis
coke
alcohol
IV drug user -
Stoke -
Hx/PE
MCA -
Aphasia
neglect
gaze preference
homonymous hemianopsia
contralateral hemiparesis -
arm/face > leg -
Stoke -
Hx/PE
ACA -
Amnesia
personality changes
foot drop
gait dysfunction
cognitive changes
contralateral hemiparesis -
leg > arm/face -
Stoke -
Hx/PE
PCA -
Homonymous hemianopia
memory deficits
dyslexia/alexia -
Stoke -
Hx/PE
Basilar -
Coma
CN palsies
apnea
visual Sxs
drop attacks
dysphagia -
Stoke -
Hx/PE
Lacunar -
Unilat pure motor or sensory
dysarthria -
clumsy hand syndrome
ataxic hemiparesis -
Stoke -
Hx/PE
TIA -
Transient neuro deficits
last < 24 hours
most last < 1 hour -
Stoke -
Dx -
CT without contrast -
ischemic vs. hemorrhagic
MRI
EKG
echocardiogram
vascular studies -
carotid US
MRA
transcranial doppler or MRA
screen for hypercoagulability
PE -
Stoke -
Tx
Preventive and Long-Term -
* Vigilance for signs of -
brain swelling
inc. ICP
herniation
* tPA -
ischemic stroke
if admin within 3 hrs.
of onset of Sxs
* ASA -
ischemic stroke presenting
within 48 hours
* no hypotension, hypoxemia,
hypoglycemia
* tx aspiration pneumonia,
UTI or DVT
Preventive & long-term Tx -
* ASA, clopidogrel or
dipyridamole/ASA
* carotid endarterectomy
* anticoags
* management of HTN, DM and
hypercholesterolemia -
Carpal Tunnel Syndrome -
What is it
Risk factors -
Median n. compression where
passes thru carpal tunnel
women 30-55
Risk factors -
repetitive use injury
pregnancy
DM
hypothyroidism
acromegaly
RA
obesity -
Carpal Tunnel Syndrome -
Hx/PE -
Wrist pain
numbness & tingling of 3 1/2
weak grip
dec. thumb opposition
thenar atrophy
nocturnal pain & paresthesias
Sxs may awaken pt. at night
relieved by shaking wrist -
Carpal Tunnel Syndrome -
Workup -
Tinel's sign -
tap
tingle
Phalen's sign -
ph-lex (flex)
paresthesias
EMG - to confirm
NCV - to confirm
eval for risk factors -
Carpal Tunnel Syndrome -
Tx -
Neutral wrist splint
modify activity
create ergonomic work envi
NSAIDs
corticosteroids -
direct injection
surgery if Sxs persist -
carpal tunnel release -
Myasthenia Gravis -
What is it -
Autoimmune
Ab that bind to postsynaptic
Ach receptors (nicotinic)
block receptors
lose receptors
young adult women
can be associated with -
thymoma
thyrotoxicosis -
Myasthenia Gravis -
Hx/PE -
Muscle weakness inc. in
periods of activity
dec. after rest
Sx come and go
onset can be sudden
fluctuating fatigable ptosis
diplopia (double vision)
dysphagia (swallowing)
dysarthria (speech)
Sxs worsen throughout day
myasthenic crisis -
so severe,
resp. failure and aspiration
secondary to weakness
often secondary to infection
(resp. muscles compromised)
ocular myasthenia -
common variant
if doesn't spread in 2-3 yrs,
probably won't -
Myasthenia Gravis -
Dx -
Edrophonium (tensilon test) -
diagnostic
abnormal single-fiber EMG
dec. response to
repetitive n. stimulation
antistriatal ab if thymoma
chest CT - eval for thymoma -
Myasthenia Gravis -
Tx -
* Neostigmine (treat Sx)
* pyridostigmine (treat Sx)
* prednisone
* plasmapheresis or IVIG -
temp relief (wks) if severe
* thymoma resection -
Amyotrophic Lat. Sclerosis -
What is it -
Progressive neurodegen. dis
unknown etiology
degeneration of motor neurons
UMN and LMN degenerate
=> resp. failure and death -
Amyotrophic Lat. Sclerosis -
Hx/PE -
Slowly progressive weakness
may have fasciculations init
UMN and LMN -
Amyotrophic Lat. Sclerosis -
Dx -
Clinical presentation
EMG and n. conduction studies
CT/MRI -
cervical spine
check for lesions
r/o systemic causes -
CBC TSH SPEP UPEP
Ca2+ PTH PFTs
urine for heavy metal -
(if h/o exposure) -
Amyotrophic Lat. Sclerosis -
Tx -
Supportive
pt. education
pulmonary specialist
riluzole -
Thiamine (B1) Deficiency -
What are Signs/Sxs -
Wernicke's
inadeq intake or absorption
excessive alcohol interferes
with GI absorption
and liver storage
acute onset -
confusion
opthalmoplegia -
nystagmus
lat. rectus palsy
conjugate gaze palsy
abnormal pupils
ataxia -
vestibular dysfunction
cerebellar dysfunction -
Thiamine (B1) Deficiency -
Pts. -
Alcoholics
dialysis
hyperemesis
starvation
cancer
AIDS
can be triggered by large-dose
glucose admin if deficient -
Thiamine (B1) Deficiency -
Tx -
Reversible almost immediately
with thiamine admin -
Korsakoff's Psychosis -
What is it -
Late complication of
untreated pts. with Wernicke's
can be triggered by
severe or repeated DTs
can be triggered by SAH and
thalamic injuries
immediate memory affected
confabulation -
Korsakoff's Psychosis -
Tx -
Prognosis good -
head injury and SAH
irreversible - others -
B12 deficiency -
What are Signs/Sxs - Subacute combined degen
-
B12 deficiency -
Pts. - Pts with pernicious anemia
-
B12 deficiency -
Tx -
B12 injections or
large oral doses -
Folate Deficiency -
What are Signs/Sxs -
Irritability
glossitis
diarrhea
depression
neural tube defects -
Folate Deficiency -
Pts -
Alcoholics - alcohol
interferes with absorption
Pts. with pernicious anemia -
Folate Deficiency -
Tx - Reversible if corrected early
-
Seizures -
General Evaluation -
. Epilepsy -
seizure d/o
2+ seizures not related
to reversible stressors
. was seizure epileptic -
Hx
inc. prolactin = epileptic
. VITAMINS
seizure caused by -
vascular
infection
trauma
autoimmune
metabolic
idiopathic
neoplasm
sychiatric (faking it)
. anticonvulsant therapy
indicated?
1st seizure not treated
when underlying cause unknown -
Partial Seizures -
What are they -
Arise from focus
limited to one side
consciousness usually not lost
can progress to generalized
simple partial & complex part -
Partial Seizures -
Hx/PE -
Simple partial -
consciousness not impaired
motor - Jacksonian march
sensory - parietal
autonomic - BP, HR, PVR
psychic - fear, deja vu
postictally -
Todd's paralysis
resolves in 1-2 days
Complex partial -
consciousness impaired
temporal lobe
auditory or visual hallucinat
deja vu
automatisms
postictal -
confusion
amnesia -
Partial Seizures -
Workup -
EEG
r/o systemic causes -
CBC
electrolytes
Ca2+
fasting glucose
LFTs
tox screen
RPR
renal panel
ESR
r/o mass -
MRI or CT with contrast -
Partial Seizures -
Tx -
Tx underlying cause
recurrent partial -
phenytoin
oxcarbazepine
tegretol
phenobarbital
valproic acid
kids - phenobarbital
intractable temporal lobe -
WADA testing
ant. temporal lobectomy -
Generalized Seizures -
What are they -
Begin diffusely throughout
both sides
consciousness always lost
postictal confusion
most common types -
tonic-clonic (grand mal)
absence (petit mal) -
Tonic-Clonic Seizures -
Hx/PE -
Start suddenly
with tonic extension of
back and extremities
rep. symm. clonic movements
incontinence
tongue biting
may look cyanotic
consciousness slowly regained
may complain of -
muscle ache
headache -
Tonic-Clonic Seizures -
Tx -
Tx underlying cause
idiopathic -
valproate - 1st line
lamotrigine - adjunctive
topiramate - adjunctive
symptomatic -
same therapy as partial sz. -
Absence (Petit Mal) Seizures-
What are they -
Begin in childhood
subside before adulthood
often familial -
Absence (Petit Mal) Seizures-
Hx/PE -
Brief, often unnoticeable
episodes of
impaired consciousness
lasts 5-10 seconds
have 100's of times/day
amnestic during and
immediately after
eye flutters or lips smack
can be precipitated by
hyperventilation -
Absence (Petit Mal) Seizures-
Evaluation -
EEG -
3 Hz per sec. spike
& wave discharges -
Absence (Petit Mal) Seizures-
Tx -
Ethosuximide - 1st line
valproic acid
zonisamide -
Infantile Spasms
(West Syndrome) -
What is it
Tx -
Syndrome -
. infantile spasms
(generalized seizures)
symmetric
tonic
5-10 at a time while drowsy
or upon awakening
. abnorm interictal EEG
. arrest of psychomotor dev.
at age of onset
starts at 3-12 months
usu male
MR
Tx -
ACTH
prednisone
clonazepam
valproic acid -
Status Epilepticus -
What is it
Common Causes -
Brain in persist. state of Sz
1 cont. seizure or recurrent
w/o regaining cons. > 30 min.
med emergency - 20% mortality
common causes -
anticonv. withdrawal/noncomp
anoxic brain injury
alcohol withdrawal
metab disturb (hypoNa+)
trauma
infection
usual cause -
subtherapeutic or
noncompliance -
Status Epilepticus -
Evaluation -
Airway, breathing, circulation
labs -
electrolytes
anticonvulsants
get Hx
look for etiology if
no prior Hx
(tumor, encephalitis, SAH)
(EEG, CT only when stable) -
Status Epilepticus -
Tx -
Diazepam or lorazepam
if continues -
phenytoin or fosphenytoin
if continues -
phenobarbital
if continues -
midazalom or propoful -
Headache -
Things to think about
(Evaluation) -
Headache new or old
characteristics
any associated Sxs
any neurological Sxs
SAH suspected? -
Migraine Headache -
What is it -
More commonly affects women
and those with family Hx
vascular & 5HT abnorm
triggers -
menses
OCP
chocolate
fasting
stress
bright lights -
Migraine Headache -
Hx/PE -
Throbbing > 2 hrs
usually lasts < 24 hrs
n/v
photophobia
sensitive to noise
"classic" migraine -
visual aura precedes
unilat
"common" migraine -
80%
can be b/l, periorbital -
Migraine Headache -
Dx -
Hx
if have focal neuro deficits-
CT or MRI
Sxs acute in onset -
r/o meningitis or SAH -
Migraine Headache -
Tx -
Avoid known triggers
aspirin/NSAIDs
sumatriptan
prophylaxis -
beta-blockers
TCAs
Ca2+ channel blockers
valproic acid -
Cluster Headache -
What is it -
Men
~ 25 y/o - age of onset -
Cluster Headache -
Hx/PE -
Unilat, periorbital
30 min. - 3 hrs.
attacks in clusters -
same part of head
same time of day
same time of year
can be precip by alcohol or
vasodilators
ipsilat tearing of eye -
Cluster Headache -
Dx - Hx
-
Cluster Headache -
Tx -
Acute therapy with
high-flow O2
(100% nonrebreather O2)
sumatriptan
corticosteroids
prophylaxis -
Ca2+ channel blockers
valproic acid
methylsergide
prophylaxis important -
by the time abortive meds take
effect, has already resolved
methylsergine (sansert) -
need drug holiday every several months to avoid risk of retroperitoneal fibrosis -
Tension Headache -
What is it -
MC type diagnosed in adults
chronic -
Tension Headache -
Hx/PE -
Tight, bandlike pain
occipital and neck
exacerbated by -
noise
bright lights
stress
fatigue -
Tension Headache -
Dx - Dx of exclusion
-
Tension Headache -
Tx -
Avoid exacerbating factors
NSAIDs - 1st line
prophylaxis -
Ca2+ channel blockers
alpha blockers
TCAs -
Benign Paroxysmal
Positional Vertigo -
What is it -
Peripheral vertigo
otoliths dislodge from
usual position
migrate over time into
semicircular canals
abnorm fluid displacement
=> vertigo -
Benign Paroxysmal
Positional Vertigo -
Hx/PE -
Sudden onset of severe
vertigo and nystagmus
vertigo with head movement in
direction of affected ear
happens turning head in bed
5 sec. - 1 min.
n/v
Sxs dec. with repetitive tests
usu h/o recent trauma -
Benign Paroxysmal
Positional Vertigo -
Dx -
Nylen-Barany Maneuver
(Dix-Hallpike) -
Benign Paroxysmal
Positional Vertigo -
Tx -
Usually subsides spontan.
in wks to months
Epley Repositioning Maneuver -
Meniere's Disease
(Endolymphatic Hydrops) -
What is it -
Peripheral vertigo
from buildup of endolymphatic
fluid in inner ear
= V and P change
risk factors -
head trauma
syphilis -
Meniere's Disease
(Endolymphatic Hydrops) -
Hx/PE -
Sudden attacks of vertigo
lasts up to 24 hours
attacks can last hrs to days
n/v
ear fullness
tinnitus
hearing loss
signif permanent hearing loss
can occur over period of yrs -
Meniere's Disease
(Endolymphatic Hydrops) -
Dx -
Audiometry -
low-freq. pure tone
hearing loss -
Meniere's Disease
(Endolymphatic Hydrops) -
Tx -
Low-salt diet
acetazolamide
acute -
antihistamines
antiemetics
benzos
if refractory -
surgical decompression