Path: Myocardial, Pericardial and Endocardial Diseases
Terms
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- clinical presentation of Myocarditis?
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many cases are asymptomatic
Acute = fever, pericarditis,EKG changes, dysarythmia, CHF. sudden death - Characteristics of Viral myocarditis
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causes lymphocytic infiltrates with myocyte necrosis
elevation of Ab titers (Coxsacie B)
classic history inc. prior upper resp tract infection - Characteristics of bacterial/ fungal myocarditis
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usually b/c of infective endocarditis os systemic infxn
Diptheric myocarditis = exotoxin produced by Corynebacterium diphtheriae - Characteristics of protozoal myocarditis
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inc. thrichonosis, toxoplasms, and Chagas' disease
Dx made by demonstration of parasitization of individual myocardial fibers - What is Chagas disease?
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cause of 25% of young adult deaths in endemic areas
flagellated trypanosomas circulate in blood, enter tissues and proliferate as amastigotes
fatality is due to acute phase of infection - What is Toxoplasmosis?
- parasitic myocarditis most often seen in the presence of immunosuppression
- Characteristics of hypersensitivity myocarditis
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typically an allergic rxn to a drug (esp antibiotics)
peripheral eosinophilia is common; cardiac symptoms are usual
usually resolves when drug use ends and does not usually damage myocardium - Characteristics of Autoimmune myocarditis
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may occur in systemic autoimmune disease
ex. lupus, scleroderma - Characteristics of giant cell myocarditis
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not a single entity but may be seen as a part of any of the other myocarditis'
seen in granulomatous disease - What are the 3 general groups of Cardiomyopathies?
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1. Dialted congestive cardiomyopathy
2. Restrictive Cardiomyopathy
3. Hypertrophic cardiomyopathy