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pharmacology - chemotherapy

Terms

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mechlorethamine
alkylates guanine, cross links DNA
cyclophophamide
alkylates guanine, cross links DNA
carmustine
alkylates guanine, cross links DNA
procarbazine
alkylates DNA RNA, and protein synthesis, idiopathic mechanism
cisplatin
alkylates DNA forming intrastrand and interstrand crosslinks
methotrexate
inhibits dihydrofolate reductase (DHFR)
5-fluorouracil (5-FU)
inhibits thymidylate synthetase (dTMP)
gemcitabine
terminates DNA synth, inhibits ribonucleotide reductase
vincristine
inhibits tubulin
vinblastine
inhibits tubulin
paclitaxel- taxol
stabilizes tubulin
etoposide
inhibits topo II
topotecan
inhibits topo I
actinomycin D -dactinomycin (ActD)
scission of DNA, intercalates DNA
doxorubicin
scission of DNA, intercalates DNA
bleomycin
bind DNA, generate free radicals, inhibit DNA ligase
imatinib mesylate
blocks Bcr-Abl kinase
trastuzumab
blocks HER2/neu receptor
rituximab
binds CD20 causing lysis
interferon
reduces myc transcription, activates a nuclease
tamoxifen
estrogen antagonist
anastrozole
aromatase inhibitor
prednisone
stimulates production of certain proteins
leuprolide
gonadotropin releasing hormone
goserelin
gonadotropin releasing hormone
flutamide
nonsteroidal androgen antagonist

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