Alzheimer's Medications
Terms
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- Tacrine brand name, dosis, uses
- Cognex, Inhibitor of acetylcholinesterase, 10 - 40 mg QID. Not used anymore for its hepatotoxycity
- Acetylcholinesterase inhibitors actions
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Inhibit the enzime that transform acethylcholine:
salivation, urination and defecation - Anticholinergic drugs
- Benadryl (dipheniramine), ipatropium, chlorpheniramina, meclizine, scopolamine, Atropine
- Donepezil drug, doses administration, side effects
- Aricept, 10-20 md QHS most used, Nausea
- Rivastigmine brand name, administration
- Exelon 1.5 - 6 mg caps, bid w/f
- Anticholinergics & short term memory
- reduces short term memory
- Galantamine brand name, doses, administration
- Razadyne, 4 mg bid or 8 mg ER qAm with meal.
- Galantamine maximum dose before hepatic or renal impairment
- Should not excede of 8 mg bid
- Cholinesterasa inhibitors drugs
- Aricept (donepezil), Razadyne (galantamine), Rivastigmine (exelon)
- Cholinesterasa inhibitors adverse effects
- n/v, bradycardia, worsen COPD or asthma, cholinergic effects (increase urination, salivation and defecation)
- Neostigmine and Physostigmine uses
- Miastenia gravis. Improves muscle strength
- Cholinesterase inhibitors drug interactions:
- Anticholinergics: antagonist effects (benadryl), antipsycotic drugs, cholinesterase inhibitors will have additive effects
- Treatment for overdose of an Cholinesterase inhibitors drug
- Atropine 0.5 - 1.0 mg IV q 3-5 min
- Namantadine Brand name, dose, anticholinergic?
- Namenda, 5 - 10 mg, initiate with 5 mg qd until 10 mg bid. Alzheimer's, no cholinergics side effects
- Namantadine MOA and side effects
- Glutaminergic agent. NMD receptor antagonist. Dizziness, confusion, constipation, h/a, rash.
- Namantadine drug interactions
- alcaline urine, increases namantadine blood levels, and side effects. May interfire with blood levels of quinine and diuretics
- NMDA drugs
- mamantadine, amantadine (symmetrel), ketamine and dextromethorphan. Do not combine then may potentiate its effects