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1.2 The Synapse and Neuron Transmitters


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What are synaptic vesicles, and where are they located?
Synaptic Vesicles are located in the terminal boutons of the presynaptic neuron and contain neurotransmitters...
What are receptor sites?
Pockets on the surface of the postsynaptic neuron which receive Neurotransmitter molecules.
The activation of the receptor site has one of two oppsoite effects on the ion channel and on the dentritic potential of the post synaptic cell... what are they?
What is EPSP?
Excitatory Post-Synaptic Potential.. more likely to generate its own Action Potential
What is IPSP?
Inhibitory Post-Synaptic Potential...less likely to generate its own action potential
How can you create action potential in the postsynaptic neuron?
Through Spatial and Temporal Summation of EPSPs
Definie Spatial Summation.
Combining the effects of many EPSPs occuring SIMULTANEOUSLY from synapses all over receptive zone of postsynaptic neuron.
Define Temporal Summation
Combining the effects of a number of EPSPs that occur within a short time at the same synapse.
Tricyclic antidepressants
Blocks reuptake of norepinephrine and serotonin inro PREsynaptic neuron, keeps them in the synapses longer
selective serotonin reuptake inhibitor (SSRI)... presynaptic cell
Monoamine Oxidase (MAO)
MAO breaks down monoamine neurotransmitters for reuse. MAO inhibitors used to treat depression, allows monoamine neurotransmitters to remain in cleft.

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