Psychiatry, Set 2, Neuro cont.
Terms
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- A. BIOGENIC AMINES
-
Dopamine
Norepinephrine
Serotonin
Acetylcholine - 1. Dopamine
-
Parkinson's
mood disorders
conditioned fear response
reward nature of drug abuse
schizophrenia + other psych. disorders - 2. Norepinephrine
-
mood
anxiety
arousal
learning
memory -
What agent converts dopamine to norepinephrine?
Where are the noradrenergic neurons located that synthesize dopamine -
beta-hydroxylase
locus ceruleus - 3. Serotonin
-
mood
sleep
pain sensitivity
appetite
sexuality
impulse control -
What agent converts TRYPTOPHAN to SEROTONIN?
Where are the cell bodies located? -
tryptophan hydroxylase
dorsal raphe nucleus -
Inc. Serotonin =
___ sex desire
___ sleep desire
___ mood
Excess leads to ____ -
decrease
increase
increase
___ leads to psychosis -
Dec. Serotonin =
___ depression
___ OCD
___ Dhronic pain syndromes
___ sleep disorders
___ anxiety disorders - all increase
- 4. Acetylcholine
- used mainly at neuromuscular junctions
-
Alzheimer's Disease results when:
cholinergic neurons ___
or
choline acetyltransferase ___ -
are lost
or
production slows - You can delay the progression of Alzheimer's by blocking the action of ___
-
AChE
Acetylcholinesterase - Histamine availability is altered by _________ and responsible for what side effects?
-
psychoactive agents
sedation, and increased appetite -
a. Dry mouth
b. Blurred Vision
c. Urinary Hesitancy
d. Consipation
Side-Effects of ___ - Anticholinergic Side-Effects
-
B. AMINO ACID NEUROTRANSMITTERS
exs: -
GABA
Glycine
Glutamate -
GABA
associated with:
inhibitory or excitatory? -
anxiety
inhibitory -
2. Glutamate
associated with:
inhibitory or excitatory? -
epilepsy, neurodegenerative disease, memory formation, cell death, Schizophrenia
excitatory -
The major glutamate receptor is NMDA (n-methyl-D-aspartate).
Drugs that block NMDA cause ___ -
psychosis
is caused by what blocked receptor ___ (ligand ___) -
C. NEUROPEPTIDES
exs: -
Endogenous Opoids
Enkephalins
Endorphins
decreased pain and anxiety
role in mood and addiction - aa. CCK and Neurotensin
- Schizophrenia
-
bb. Somatostatin
Substance P
Vasopressin
Oxytocin
VIP - Mood disorders
-
cc. Somatostatin
Substance P - Huntington's disease
-
dd. Somatostatin
VIP - Alzheimers
-
ee. Substance P
CCK - anxiety disorders
- ff. Substance P
- pain and aggression