Everything else...
Terms
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- 3 d's of geriatric neuropsychiatry
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Demetia = psychiatric and cognitivce
Delirium = abrupt onset of cognitive loss
Depression - Demetia-related illness that affects younger people with more personality and behavioral problems?
- frontotemporal dementia (FTD)
- amyloidopathy
- AD
- synucleinopathy
- diffuse lewy baody dementia (DLBD) (associated with PD)
- tauopathy
- FTD & progresive supranuclear palsy (SPS)
- Basalis of Meynert
- Cholinergic (damaged in AD)
- Raphe nuclei
- serotonin
- Ventral tegmental area
- dopaminergic
- Lewy Body
- PD & DLBD
- Picks bodies
- FTD
- Loss of posterior columns & spinocerebellar pathways
- Friedreich's ataxia
- Must have a cognitive problem which involves more than 1 cognitivie domain
- dementia
- first thing to go in dementia?
- loss of instrumental daily activities
- depression is very frequent in this dementia disorder
- mild cognitive impairment (MCI)
- Compulsions and disinhibitions are very frequent in this dementia disorder
- FTD
- partients have no evidence of forming a memory trace
- amnestic prodrome (AD!)
- 3 key characteristics of DLBD
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1)Parkinsonism
2)fluctuations in alertness/cognition
3)visual ahllucinations
-not as severe an amnestic problem as AD; more problems in teh visu-spatial and executive functions - Semantic dementia aka?
- Fluent aphasia - loss of word meaning
- FTLD can be caused by ?
- Tau derangements - Picks bodies & Tangles
- with Vit B12 check for increase in?
- MMA & homosystine
- in young people w/AD think
- pre-senilin-1 gene mutation
- In AD (vs. MCI)
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-involves more anterior cingulated gyrus
-lateral pariteal lobes involved
-frontal lobe reduction in metabolism - Treatment for dementia
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Vit E, Curcumin, Fish oil extract
Cholinesterase inhibitors & NMDA receptor antagonists