lab 5
Terms
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- types of post synaptic cells
-
neuron
glandular tissue
muscle cell - types of neuron-neuron synapses
-
axosomatic
axodendritic
axoaxonic - NT binding to postsyanptic receptor causes...
- ...open specific ion channels
- NT bindindg to presynaptic receptor causes...
- ...modulation of NT synthesis or release; feedback
- two main mech for terminating synaptic signal
-
enzyme degredation
uptake - agnoist
- mimics effect of NT of interst at synapse
- endogenouse
- naturally occuring w/in tissue
- exogenous
- artificially put into tissue
- NT
- endogenous agonist at own receptors
- direct agonist
- bind to NT receptor protein
-
indirect agonist
e.g. -
dont bind to receptor but affect action of NT indirectly
e.g. drugs that facilitate synthesis or release of transmitter or prevent enzymatic degredation - antagonist
- reduce/blocks action of another agonist
- direct antagonist
- bind to receptor to prevent agonist from binding
-
indirect antagonist
e.g. -
dont bind to receptor protein but interfere indirectly
e.g. drugs that decrease NT sytnehsis or release, enhance enzymatic degradation of NT in synaptic cleft - selective
- act on one receptor subtype but not another
- nonselective
- act on all receptor subtype of given NT