Untit 6 & 7
Terms
undefined, object
copy deck
- substntia niagra
- destuction of the neuron that proudces dopamine
-
tremo
-rest - tremor at first lessens on focus
-
tremor
-intent -
-BET-Begign Essential Tremmor
-less now and worsens when you try to concentrate -
Parkinson's
cause -
-drop in amt of dopamine
1 decrease number of nerve cells that produce dopamine
2 level of MAO unchanged
3 little is secreated and is broken down by MAO
4 imbalance of dop to ach causeing decreased balance and coordination -
Pakinson's
s/s -
-tremor
-muscle tightness
-joint stiffness
-problems with movement
and ambulation(bradykinesia)
-includes walking and talking swallowing and chewing - EPS
-
Extra pyramidal S/E
pseudoparkinsons - psychoactive properties
- depressent effect on cns
- dopaminergic agents
-
levadopa(larodopa)
cabidopa(lodosyn)
p levadopa/carbidopa(senemet)
amatadine(symmetrel) - Anicholenergic agents
-
P benztropine(cogentin)
trihexyphenidyl(artane) -
levadopa/carbidopa
dosage -
P
Sinemet
PO 1:10 =25:250 car->leave tid -
levadopa/carbidopa
pk -
po-> well absorbed
pro bound car->36%
1/2 -> 1-2hrs
excreated ->urin -
levadopa/carbidopa
pd -
po: onset 15min
p 1-3hrs
d 5-12hrs -
levadopa/carbidopa
Theraputic effects - treat tremor and rigidity
-
levadopa/carbidopa
contraindications -
-narrow agle glacoma
-sever cardiac, hepatic, renal problems
CAUTION: hepatic uslcers and psych disorders -
levadopa/carbidopa
S/e - A N V dysphaia, fatigue, dizziness, ha, drymouth, bitter tase, twitching, blurred vision, insomnia, inconuntary chreiform, palpitations, orthostatic hypotension, urinary tetention, psychosis, severe depression hallucinations