Neuro Pharm 9
Terms
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- Phenytoin
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- AED for partial and tonic-clonic seizures
- interacts w/ CYP2C9 and CYP2C19 - Carbamazepine
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- AED for partial and tonic-clonic seizures
- interacts w/ CYP3A4, CYP2C8, CYP1A2 - Lamotrigine
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- AED for partial and mixed seizures
- May interfere with pathologic glutamate release
- interacts w/ UGT 1A4 - topiramate
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- AED for partial and tonic-clonic seizures
- antagonizes glutamate action at AMPA/kainate GluR’s and inhibits carbonic anhydrase - Barbiturates for epilepsy
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- phenobarbitol
- for partial and tonic-clonic seizures, and status epilepticus
- prolong GABA-mediated chloride channel openings - gabapentin
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- for partial and tonic-clonic seizures
- increase neuronal GABA concentration - enhances GABA transmission, etc - valproate
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- for partial, tonic-clonic, and abscence seizures
- increase neuronal GABA concentration - enhances GABA transmission, etc - ethosuximide
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- for abscence seizures
– Blocks “transient†(T-type) calcium channels - benzodiazapine for epilepsy
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- diazepam
- for status epilepticus - fosphenytoin
- a phenytoin for status epilepticus