winter 2
Terms
undefined, object
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- omeprazole
-
PPI
binds cysteine residue of H+/K+ ATPase - Ranitidine
-
H2 receptor antagonist
H2 blockade in gastric parietal cells - blocks Gs mediated receptors (so no increase cAMP - PKA - ACh or gastrin release) - Cipro, Levoquin
-
Fluoroquinolones
DNA gyrus inhibitors good for (-) - Trimethoprim
- Dihydrofolate inhibitor
- Sulfamethoxazole
-
a sulfamide
PABA analogue - decrease pyrimidine synthesis -
Keflex
Cefaclor
Cefriaxone
Cefepime -
cephalosporins in increasing generations (from (+) to (-))
PBP (D-Ala-D-Ala) binders, pretty resistant to Beta-lactamases - Clarithromycin
-
Macrolides
Binds 50s and accumulate in macrophages - Cyclophosphomide
-
mustard
alkylator
binds guanine N-7 (S phase)
Mesna antidote (traps Acrolein - the converted drug form) - Carmustine
-
nitrosureas
alkylator
binds O-6 guananine (S phase)
*Crosses BBB - Mechlorethamine
-
also a mustard
alkylator
binds N-7 guanine - Cisplatin
-
Platinum analog
alkylator
guanine binder
cancer of the goods (breast, testicular)
*nephro and neuro tox (CN8 - deafness) w/out BMS - Doxorubicin
-
Antibiotic
Increases free radicals (Fe and O2 complex)
*CV tox and turns urine red w marked alopecia - Bleomycin
-
antibiotic
free radical formation
*hydrolase for the drug deficient in the lung - leads to lung disease - Busulfan
-
alkylator
also lung problems - vinblastin
-
binds tubulin - mitotic spindle can't form
(M phase)
marked BMS - Vincristine
-
binds tubulin - mitotic spindle can't form (B subunits)
(Mphase)
Neurotox - areflexia, peripheral neuritis) w paralytic ileus
- Paclitaxel
-
hyperstabalizes microtubules so the mitotic spindle can't break down and enter anaphase
(M phase)
can have hypersensitive rxn
- 6-MP
-
purine analogue - activated by HGPRTase
(S phase)
antidote w allopurinol
(same thing for gout) - 5 - Fu
-
pyrimidine analogue - complexes with folic acid - inhibiting thymidylate synthase so dTMP can't be formed
(S phase)
- Methotrexate
-
dihydrofolate reductase inhibitor - can't form dTMP
(S phase)
*myelosuppression reversible with leuvocorin
teratogenic - Cytarabine (Ara-C)
-
Pyrimidine antagonist via inhibition of DNA polymerase, inhibiting elongation
thrombo, megaloblstic anemia - amitryptyline
-
TCA
non-selective 5HT and NE reuptake inhibitor
*3 c's, 5HT syndrome, etc - Fluoxetine
-
SSRI
5HT syndrome - Phenelzine
-
MAOI (inhibits MAOa and MAOb and NE)
HTN crisis and 5HT syndrome
- Atomoxetine
-
SNRI - just NE reuptake inhibitor for ADHD
SE like TCAs - Lithium
-
decrease recycling of inositol leading to decreases PIP2 and cAMP
PNMNOP - Valproic Acid
- Na+ channel blocker (in inactive state), inhibits GABA transaminase...so increase [GABA], blocks T-type Ca2+ channels (blocking "bursting" in the thalamus)
- Carbamazapine
- Na+ channel blocker
- Haloperidol
-
Fluphenazine
blocks D2 receptors: increase cAMP
extrapyramidal - Chlorpromazine
-
Typical anti-psycotic
blocks D2 receptors but slow acting
EPS and FEVER - Resperidone
-
Atypical anti-psychotic
blocks D2, 5HT2, histamine and alpha receptors
fever EPS that typical anti-psychotics
- clozapine
-
atypical anti-psychotic
5HT receptors - BMS - lead to agranulocytosis