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Viral Pathogenesis 2 9/12/05

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Imfluenza, Rhinovirus, coronoavirus, and Rotaviruses are all types of what kind of infections?
Localized
Hepatitus B, Poliovirus are responsible for what types of infections?
Systemic
What do you call organ and tissue specificity of a virus w host recep recog, entry, and inherent gene expression?
Tissue Tropism
What are 2 examples of tissue tropism gene expression?
JC Polymyxavirus enhancers and Paramyxovius glycoprotein cleavage
Infants less susceptable to ___ and ___ but more suscep to _______
polio, hep A

rotavirus,RSV
PABS severe during pregnancy
polio, hep A and B and smallpox
_______ increases severity of what disease?
measles
____ usually benign but can cause fatal pneumonia in transplant patients
CMV
___ AKA silent infxs-no symptoms present, 2- EBV CMV
subclinical
_____-signs of obvious diease (chicken pox)
Clinical disease
Herpes,Varicella, Shingles,CMV, EBV (enter sensory ganglia, react along periph nerve)are all types of what kind infx?
Latent-inactive most of time
Rubella, CMV-infant, hep B in utero and RNA viruses (HIV) are what types infxs?
Chronic infxs-always at low levels
What are the 2 most significant viral cancers?
cervical and liver
What are 4 types of DNA /RNA cancers?
BHKC
Burkitts
Hodgkins
Kaposis
Cervical
_hits needed (first insertion promotor by virus, and second insert into repressor) to cause onco activation?
2
What inclusion body corresponds to herpes?

to Rabies?
Cowdry

Negri
_______ (anaphylaxis) uses IgE, degranulation, cuase asthma. Ex. Rhinovirus, RSV (resp sync)
Type I Anaphylaxis
______ (cytotoxic) IgG, cell lysis, EBV B cells, RBC/platelet lysing, anemia thrombocytopenia
Type II
____(immune complex rxns) soluble antigen antibody complexes, neutrophils inflamm,Hep B,Rubella, HPV, Rash, vasculitis, arthralgia
Type III
_____ (delayed, cell mediated) T cells macrophages, toxic releases, liver damage-hep B,Coxsackie-cardiomyopathy autoimmune
Type IV

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