Viral Pathogenesis 2 9/12/05
Terms
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- Imfluenza, Rhinovirus, coronoavirus, and Rotaviruses are all types of what kind of infections?
- Localized
- Hepatitus B, Poliovirus are responsible for what types of infections?
- Systemic
- What do you call organ and tissue specificity of a virus w host recep recog, entry, and inherent gene expression?
- Tissue Tropism
- What are 2 examples of tissue tropism gene expression?
- JC Polymyxavirus enhancers and Paramyxovius glycoprotein cleavage
- Infants less susceptable to ___ and ___ but more suscep to _______
-
polio, hep A
rotavirus,RSV - PABS severe during pregnancy
- polio, hep A and B and smallpox
- _______ increases severity of what disease?
- measles
- ____ usually benign but can cause fatal pneumonia in transplant patients
- CMV
- ___ AKA silent infxs-no symptoms present, 2- EBV CMV
- subclinical
- _____-signs of obvious diease (chicken pox)
- Clinical disease
- Herpes,Varicella, Shingles,CMV, EBV (enter sensory ganglia, react along periph nerve)are all types of what kind infx?
- Latent-inactive most of time
- Rubella, CMV-infant, hep B in utero and RNA viruses (HIV) are what types infxs?
- Chronic infxs-always at low levels
- What are the 2 most significant viral cancers?
- cervical and liver
- What are 4 types of DNA /RNA cancers?
-
BHKC
Burkitts
Hodgkins
Kaposis
Cervical - _hits needed (first insertion promotor by virus, and second insert into repressor) to cause onco activation?
- 2
-
What inclusion body corresponds to herpes?
to Rabies? -
Cowdry
Negri - _______ (anaphylaxis) uses IgE, degranulation, cuase asthma. Ex. Rhinovirus, RSV (resp sync)
- Type I Anaphylaxis
- ______ (cytotoxic) IgG, cell lysis, EBV B cells, RBC/platelet lysing, anemia thrombocytopenia
- Type II
- ____(immune complex rxns) soluble antigen antibody complexes, neutrophils inflamm,Hep B,Rubella, HPV, Rash, vasculitis, arthralgia
- Type III
- _____ (delayed, cell mediated) T cells macrophages, toxic releases, liver damage-hep B,Coxsackie-cardiomyopathy autoimmune
- Type IV