Immunoglobulins Test 1
Terms
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- The two complementary systems of the immune response are
-
1- Humoral immune system.
2- Cellular immune system. - Immunoglobulins are produced by
- B Lymphocytes or B Cells
- B lymphocytes complete their development in
- Bone marrow
- The cellular immune system depends on the action of
- T Lymphocytes
- The basis of affinity chromatography when we're separating antibodies is
- The antibody reacts with the hapten very specifically
- L2H2
- 2 Heavy chains + 2 Light chains
- Immunoglobulins are classified into 5 classes according to the nature of their heavy chain
-
1- IgG(Gamma.)
2- IgM(Mu.)
3- IgD(delta.)
4- IgA.(Alpha)
5- IgE(epsilon.) - The light chains are either
- Kappa or lambda
- The variable regions form the
- antigen binding site(Fab)
- Papain ckeaves the antibody molecule
- at the hinge region into 3 fragments.
- IgM is the
- first antibody produced in the early stages of immune response
- IgM level in serum is
-
8-10% of the total antibody percentage in serum.
Pentameric structure. - IgM class is
- macroglobulins existing in pentamertic form.
- IgG is
-
the main serum antibody 75-80% of the total plasma antibody. The only antibody which passes to the fetus, memory B cells.
monomer. - IgA is found mainly in
-
secretions, saliva, tears. Initial defense against bacterial and viral pathogens.
Monomer, Dimer or trimer, - IgE
-
0.04 in serum, they anchor to mast cells stimulating release of histamine.
Monomer - IgD
- has no clear function.
- Which Ig has the greatest molecular weight?
- 950, IgM
- Which Ig has the lowest MW?
- IgG
- The molecular wight of IgA is
- 170 monomeric up to 720 polymeric
- Molecular weight of IgE is
- 190
- Molecular weight of IgD is
- 160
- The carbohydrate content of IgM is
- 12%
- The carbohydrate content of IgG is
- 3%
- the carbohydrate content of IgE is
- 12%
- The carbohydrate content of IgD is
- 13%