Mixed pharm

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Combination of mixing Lasix and Digoxin in rx of CHF.: Lasix will increase the cardiac toxicity of Digoxin.
Propranol with nitroglycerin to rx angina for what reasons?: 1.block excess tachycardia
2.decrease work of myocardium.
3.reduce O2 consumption of myocardium.
4.increase collateral circulation

(does not increase left ventricular end diastolic volume).
What drug antagonizes the vasodilating and brochodilating actions of Proternol?: Cromolyn Sodium.
Which drug is both alpha and beta adrenergic receptor blockers (in rx HTN)?: Labetalol.
Which anti-convulsant drug causes ataxia, nystagmus, and vertigo as SE?: Tegretol.
MOA of Terbutaline?: Beta 2 agonist.
What's another alternative to rx Herpes simplex?: Vidarabine.
What's the main adverse effect of Erythromycin?: Cholestatic hepatitis.
Rx of Pseudomonas aeruginosa?: Cefoperazone.
MOA of cyclophosphamide?: Alkylating agent.
Alternative drug to rx N.Gonorrhea in patients allergic to penicillin?: Spectinomycin.
Bethanechol can result in _____?: aggravation of peptic ulcer.
Effects of propranolol?: Blockers that dilates arterioles and venules.
SE of doxycycline?: Photosensitivity rash.
Limited use of what anti-convulsive drug b/c due to its hepatotoxicity?: Valproic acid.
Drugs that have increased sympathetic activity and reflex tachycardia as SE?: Nitroglycerine, diazoxide, hydralazine, minoxidil. (Not clonidine).
Penicillinase producing Staph infection can be treated by?: Nafcillin.
When using vincristine, patient should be monitored for?: Neurotoxicity.
What's a good drug both treating HTN and vasospastic angina?: amoldipine (Ca channel blocker)
What's the major SE of digoxin toxicity?: Cardiac and CNS adversities: bradycardia, delirium, hallucination, visual disturbances (yellow vision), atrial fibrillation (partial AV block).
SE of Lovastatin (HMG-CoA reductase)?: Diffuse muscle pain and weakness. Elevated serum creatine kinase level.
Antiarrhythmic of choice for most acute supraventricular tachycardia?: Adenosine.
Which drug causes hemorrhagic cystitis?: Cyclophophamide.
What first-line TB drug could interfere w/ effective levels of HIV drugs usch as protease inhibitor?: Rifampin (induces metabolism of several other drugs)
Risk of kerosene OD?: Pulmonary toxicity (b/c kerosene have low viscosity and surface tension properties--> move over the tissue surface and move up the esophagus and may enter lung).
Clinical picture of aspirin OD?: Metabolis acidosis, respiratory alkalosis, dehydration, hyperventilation, hyperthermia.

(salicylates uncouple oxidative phosphorylation-->energy that normally would be converted to ATP is lost as heat. Respiratory alkalosis is compenstaed by renal loss of bicarbonate. Salicylates result in formation of lactic and pyruvate--> metabolic acidosis.)
DOC for bacteroides fragilis.: Metronidazole.
DOC for Bordetella pertussis.: Erythromycin.
Acellular pertussis vaccine (at 2, 4, 6 months).
DOC for Borrelia burgdorferi (3).: Doxycycline, Penicillin G, ceftriaxone.
DOC for Chlamydia psittaci.: Tetracycline.
DOC for Chlamydia trachomatis (2).: Tetracycline, erythromycin.
DOC for clostridium difficile.: Vancomycin, metronidazole.
DOC for clostridium tetani.: Toxoid vaccine (2, 4, 6, 18 months). Booster every 10 yrs. Penicillin.
DOC for Corynebacterium diphtheriae.: Penicillin. Erythromycin.
Inactivated toxoid vaccine.
Antitoxin (neutralized unbound toxin).
DOC for Coxiella burnetti.: Tetracycline.
DOC for Enterococci faecalis.: Penicillin and an aminoglycoside.
Vancomycin.
DOC for E.Coli.: UTI: ampicillin or sulfonamides, TMP-SMX.
Sepsis: Aminoglycoside + 3rd gen cephalosporins.
Neonatal meningitis: ampicillin + cefotaxime.
Traveler's diarrhea: rehydration.
DOC for Gardnerella vaginalis.: Metronidazole.
DOC for Haemophilus ducreyi.: Nafcillin. Erythromycin. Tetracycline.
DOC for Haemophilus influenzae.: Hib vaccine (B type capsule cnjugated to diphtheria toxoid as a carrier protein).
Ceftriaxone.
(household contacts rx w/ rifampin for meningitis prophylaxis)
Ampicillin.
DOC for Helicobacter pylori.: Triple therapy.
(1) amoxicillin, metronidazole, bismuth.
(2) amoxicillin, omeprazole, ranitidine.
DOC for Klebsiella pneumoniae.: Cephalosporins.
DOC for Legionella pneumophila.: Erythromycin.
DOC for Listeria monocytogenes.: Ampicillin.
DOC for Bacillus anthracis.: Ciprofloxacin.
DOC for mMycobacterium avium-intracellulare (MAC).: Amikacin + doxycycline.
DOC for Mycobacterium leprae.: Dapsone and rifampin for tuberculoid form.
Clofazamine, dapsone, rifampin for lepromatous form.
2 yr rx.
DOC for Mycobacterium tuberculosis.: Isoniazid, rifampin, pyrazinamide for 6-9 months.
DOC for Mycobacterium pneumonia.: Erythrymycin.
DOC for Neisseria gonorrhoeae.: Erythromycin or silver nitrate in neonates.
Ceftriaxone; spectinomycin and tetracyclne.
DOC for Neisseria meningitidis.: Rifampin, penicillin G,
DOC for Nocardia asteroides.: Sulfonamides.
DOC for Pseudomonas aeruginosa.: Aminoglycoside or 3rd gen cephalosporin.
Penicillin + pipercillin + aminoglycoside.
DOC for Rickettsia prowazeki, rickettsii, typhi.: Tetracycline.
DOC for Shigella.: Ampicillin.
3rd gen cephalosporin,
TMP-SMX.
quinolone.
DOC for Staph aureus.: Vancomycin (MRSA),
Cephalosporin,
Methicillin
DOC for Campylobacter jejuni: Erythromycin
DOC for Salmonella typhi.: Chloramphenicol,
ceftriaxone
DOC for Staph epidermidis.: Vancomycin.
DOC for Staph saprophyticus.: Quinolones.
TMP-SMX.
DOC for Strep agalactiae: (Group B strep)
Ampicillin before delivery.
Penicillin G.
DOC for Strep pneumoniae.: Penicillin and erythromycin.
Intermediate resistance: ceftriaxone.
Highly resistant: vancomycin.
DOC for Strep pyogenes.: Penicillin G. If allergic, use erythromycin.
DOC for Treponema pallidum.: Penicillin.
DOC for Trpheryma whippelli.: TMP-SMX.
DOC for Vibrio cholerae.: Rehydration, tetracycline.
DOC for Yersinia pestis.: Streptomycin/ tetracycline.
DOC for Chlamydia pneumonia.: Tetracycline.
DOC for Proteus.: TMP-SMX.
DOC for Strep viridan.: Penicillin.

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