boards 1- micro/path
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- erythrogenic exotoxin
- strep pyogenes
- scarlet fever
- erythrogenic toxin
-
specific for the cells of
mucous membrane of intestine - enterotoxins
- botulism
- clostridium
- tetanospasm
- tetanus
- bacterial dysentery
- shigella
- food poisoning
- staph aureus
- diptheria
- corynebacterium dipth
- no hemolysis
- gamma hemolytic strep
-
incomplete hemolysis
green - alpha hemolytic strep
-
hemolysis
clear - beta hemolytic
-
beta hemolytic -
group A -
erythrogenic toxin
hyaluronidase
streptokinase - hemolysins
- lysis of erythrocytes
- makes hemolysins
- strep
-
beta hemolytic
Group A -
pathogenic
cell wall M protein -
beta hemolytic
Group A
prototype - S. pyogenes
- phase of bacteria growth
-
lag >
exponential >
stationary >
death -
cells metabolically active
not dividing - lag phase
- exponential growth phase
- log phase
- fastest growth
- log phase
- cidal antibiotics work at this phase
- log
- endotoxins
- gram -
- bacterial gram - cell
- LPS
- endotoxin
- gram -
- pathogenic effects of endotoxin
- complement cascade
- exotoxin
-
gram -
gram + - free endotoxin
-
inflamed ging
dental plaque -
inflammaton
resorption of bone - LPS
- intiate perio dx
-
plaque bacteria that release
-hyaluronidase
-collagenase
-chondroitin sulfatase
-elastase
-protease - suppurative infections
- staph aureus
- acute onset food poisoning
- STAPH aureus
- staph cell wall
- protein A
- staphylokinase
- s aureus
- streptokinase
- hemolytic streptococco
-
staphlokinase
streptokinase
urokinase - plasminogen > plasmin
-
staphlokinase
streptokinase
urokinase
USED FOR - removal of blood clots
- most # in oral cavity
- strep
- strep cause
-
pneumonia
rheumatic fever
heart valve infections -
produce
HYALURONIDASE -
strep
clostridium
staph - fibrinogen > fibrin
- coagulase
- staph aureus >
-
coagulase
phospholipase - phospholipase
- lyse RBC
- dissolves blood clots
-
fibrinolysis
staphylokinase
streptokinase - destroys RBC
- lecthinase
- acid fast stain
- mycobacterium TB
- PPD
- delayed hypersensitivity rxn
-
produce neither
exotoxins
endotoxins - mycobacterium TB
- mycolic acids
- mycobacterium
- primary lesio of TB
-
tubercle
ghon focus - actinomycetes
-
streptomyc
norcardia - indicator of virulence
- capsule
-
involved in energy transformation =
oxidative phosphorylation - cell membrane
- antiphagocytic
- polysaccharide capsule
- polysaccharide capsule =
- streptococcuc pneumoniae
- technoic acid
- gram +
- murein
- gram +
- attachment site for bacteriophage
- teichoic acid
- cell envelope=
-
GRAM NEGATIVE
LPS
protein
phospholipid - disseminated infection
- viremia
- susceptible to cirulating antibodies
- viremia
- sepsis
-
staph aureus
e.coli
kleb -
gram -
facultative -
ecoli
vibrio
pasteurella
hemophilus - enterobacteriaceae
-
e coli
salmonella
shigella
kleb
yersinia - E coli
-
UTI
diarrhea
foodborne dx - spirochete
-
trponema
borrelia -
gram -
aerobic
rods/cocci -
pseudomona
bordetella
neisseria
legionella -
gram -
anaerobic
rods/cocci -
bacteriodes
fusobacterium
prevotella -
gram +
cocci -
staph
strep
entero
peptostrp - endospore
-
bacillus
clostridium -
gram +
rod - lactobacillus
-
gram +
rod
irreg -
corynebacterium
actinomyces -
impetigo
cellulitis - strep pyogenes
- rheumatic fever
- strep pyogene
- acute poststreptococcal glomeruloneph
- strep pyogene
-
neonatal
pneumonia
meningitis
sepsis -
group B
strep
s. agalactiae - strep pyogenes >
- exotoxins
- frequent bacterial pathogen
-
hemolytic strep
group A - strep throat
- strep pyogenes
- fixed phago
-
1-macrophage
2-reticuloendo - free phago
-
in blood
leukocyte - transcription
-
dna > mRNA
by DNA dependent RNA polymerase - capsule prevents
- opsonization of cells by complement
- coating of organisms to speed up phagocytosis
- opsonization
- plasminogen > plasmin
- urokinase
- obligate intracellular parasite
- viruses
- lipoprotein envelope
- viruses
- dont contain organelles
- viruses
- replicate by mitosis
- eukaryotes
- replicate binary fission
- prokaryotes
- membranes contail sterol
- eukaryotes
- mycoplasms contain what in membrane
- sterol
- true nucleus
- eukaryotes
- anaerobic process of glucose metabolism is in
- cytoplasm
- aerobic cycle
- mitochondria
- formation of ATP during electron transfer
- oxidative phosphorylation
- aerobic oxidative phosporylation
-
terminal hydrogen acceptor=
oxygen - anaerobic oxidative phosphorylation
-
terminal hydrogen acceptor=
nitrate
sulfate - fermentation
- substrate phosphorylation
-
formation of ATP
not coupled to
electron transfer - substrate phosphorylation
-
substrate phosphorylation
final hydrogen acceptor= - pyruvate
- adult perio bacteria=
-
porphyromona
prevotella
bacteroides
campylo -
20-35
perio dx > - rapidly progressing perio
-
depressed neutropil chemotaxis
inflammation
rapid bone loss - rapid perio dx
-
superoxide dismutase
catalase -
byproducts of
aerobic metabolism
hydrogen peroxide - hydrogen > water & oxygen
- catalase
- free superoxide radicals > h2o & hyrdrogen peroxide
- superoxide dismutase
-
have no
1-superoxide dismutase
2-catalase - obligate anaerobes
- ATP generating system is dependent on oxygen=hydrogen acceptor
- obligate aerobes
- asexual reproduction
- spores
- detected using ELISA
- toxin=E.coli
- cystitis
-
UTI
Ecoli - membraneless in prokaryotic cells
- nucleoid
-
no nuclear membrane
no nucleolus
no mitotic apparatus
no histones - nucleoid
-
-extrachromosomal
-circular DNA
-replicate independent of chromosome - plasmid
-
DNA move within/btw
bacteria
plasmid
bacteriophage - transposons
-
one bacterium to the next >
change in phenotype of 2nd - transformation
- ANUG
-
prevotells intemedia
spirochtes - in perio dx
- IgG
-
strep mitis
strep sanguis
actinomyces viscosus
staph epidermis - Sub -G
- spirochete invasde
-
epi
CT -
dissolves fibrin in
1-clot
2-thrombi
3-emboli - streptokinase
- rapidly destroys tissue
- exotoxin B
- TSST
- pyrogenic exotoxin A
- not inactivated by oxygen
- streptolysin S
- not antigenic
- Streptolysin S
- degrades ground substance hyaluronic acid of tissue
- hyaluronidase
- primary lung lesion
-
TB
ghon focus
tubercle - leprosy
- mycobacteria leprae
- hyaluronidase made by
-
strep
staph
clostridium - dissolves clots
-
fibrinolysins
staphlokinase
streptokinase - lyse RBc
- phospholipase
-
destroys RBC
a/w
clostridium perfringens - lecithinase
- endotoxins >
- gram -
- LPS
- endotoxin
- activate complement cascade
- endotoxin
- outer membrane
- endotoxin
- LPS effect
-
inflammation
bone resorption - chemotactic effect
-
on neutrophilic granulocytes
= endotoxin -
hyaluronidase
collagenase
sulfatase
elastase > - plaque bacteria
- protect cells against phagocytosis by eukaryotes
- capsule
- antiphagocytic=
- polysaccharide capsule
- strep pneumonia
- antiphagocytic
- oxidative phosphorylation
- cell membrane
- removal of blood clots
-
staphlokinase
streptokinase
urokinase