FA Antifungals 174-175
Terms
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- Binds ergosterol and forms membrane pores (2)
-
Amphotericin B
Nystatin - Inhibits ergosterol synthesis
- Fluconazoles, "-azoles"
- Inhibits DNA syn by conversation to fluorouracil, which competes with uracil
- flucytosin
- inhibits cell wall syn
- caspofungin
- inhibits squalene epoxidase
- terbinafine
- interferes with MT function; disrupts mitosis
- griseofulvin.
- Clinical use of Ampho B
-
Systemic mycoses and OI
Intrathecally for fungal meningitis - fever/chills, hypotension, nephrotox, arrhythmias
- Amphotericin B
- use for nystatin
-
oral candidiasis;
topical for diaper rash or vaginal candiasis - use for -azoles
-
systemic mycoses
Fluconazole - cryptococcal meningitis in AIDS and candidal infections
Ketoconazole - Coccidioides, Histoplasma, Blastomyces, Candida; hypercortisolism - gynecomastia, liver dysfunction, fever, chills
- -azoles
- systemic fungal infections like Candida and cryptoccus; major SE is bone marrow suppression
- flucytosine
- used for invasive aspergillosis
- caspofulgin
- used to treat dermatophytoses, especially onchyomycosis
- terbinafine
- used for oral tx of supf infections; inhibits growth of dermatophytes like tinea, ringworm
- griseofulvin
- teratogenic, carcinogenic, confusion, H/A, inc warfarin metabolism
- griseofulvin