I&I Effectors against intracellular & antivarals
Terms
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- Name the Effectors for Intracellular Immune response
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(in order of appearance with peak in parenth)
INF (2 days)
NK (4 days)
Neutralizing ABs & CTLs(7-10 days) - Mediators in NK cells
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Perforins (holes like C9) Granzymes (DNA damage)
IFN g (activate MPs) - Activation of Tc's
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IL-2 (from Th1's)
requires MHC I & II
MHC I: APC + antigen stimulates expression of IL-2 R on CD8 T (B7 binds CD28)
MHC II: Th1 bound to APC + Ag at same time as CD8 is bound, releases IL-2 - Mediators from Tc's
- granzyme, perforin, cytokines (TNF & IFN)
- ADCC
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NKs working with Neutralizing ABs
activation of Fc R on NK
important for worms & tumors
IgG & IgE
(no Ag R on NK) - MOA for Rimantidine
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Uses M2, interferes with uncoating of Influenza A only
Prophylactic within 24 hours of exposure
used w/L Dopa in Parkinson's - MOA for Omseltavir
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(& Zanamavir)
Neuraminidase inhibitor
Prevents viral release
Influenza A & B - MOA for Acyclovir
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recognizes thymadine kinase
inhibits DNA synthesis
HSV & EBV (not CMV) - Gangcyclovir
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for CMV, inhibit viral DNA synthesis
not as specific as Acyclovir
BM tox, Nephrotox, GI
contraindicated w/AZT (b/c BM) - Ribavirin
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inhibits viral mRNA & 5' cap
BM tox, Nephrotox, GI
Hanta, RSV bronchiolitis & pneumonia
Use w/interferon for Hep C - Idoxuridine
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BM toxicity, carcinogenic, teratogenic
MOA is DNA damage
Used topically for HSV kerititis