Polio
Terms
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- Describe the structure of Polio virus.
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ss+RNA
-Spherical
-Acid stable - What is the Viropexis?
- Endocytic property that facillitates the energy dependent process of penetration and uncoating.
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T/F
99% of polio infx are subclinical. - True and only a minority of cases develop into aseptic meningitis, even fewer into paralytic polio.
- What is Progressive Post-Poliomyelitis muscle atropy? What is this do to?
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-25-40% of earlier infxs suffer additional muscular degeneration - yrs later.
-Not due to persistence of virus, rather effect of aging. - Where is the site of the primary replication of polio? Primary viremia?
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-Oropharynx mucosa, tonsils and lymph nodes of neck.
-Viremia in Peyers Patches and mesenteric lymph nodes. - Two ways paralysis can occur?
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-direct destruction of neurons by virus or
-edema induced damage. - 3 ways we see polio infx in US.
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-Immunocompromised vacinnee
-imported
-grandparent with dec. imm., changes recently vaccinized baby. - 3 advantages of IPV
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-IPV can be incorporated with multiple vaccines.
-excludes potential for mutations.
-Can be used in immcompromised patients.
-Reduces spread of live polio. - 3 disadvantage of IPV
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-Repeat boosters are required.
-No local intestinal immunity.
-Expensive - 3 advantages to OPV.
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-Confers both humoral and intestinal imm.
-Imm may be life long.
-Quickly induces Abs.
-Oral
-Inexpensive - 3 disadvantages of OPV.
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-Virus might mutate.
-Vaccine can spread virus to others and environment.
-Can't give to immunosuppressed. - Starting from the 70s, tell the story of the polio vaccine.
- OPV was implemented in the 70s and after several cases of polio each year, IPV was re-implemented in 2000.