Gram (-) GI
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- Rapid test to detect H. pylori:
- urease
- E. coli toxin that is cholera-like, increases adenylate cyclase/cAMP via ADP ribosyl transferase activity that stimulates Gs
- Heat Labile (HT) toxin
- E. coli toxin that activates guanlyate cyclase/cGMP, hypersecretion of Cl
- Heat Stable (ST) toxin
- Antigens of Enteric bacteria:
- Exotoxins (O antigen). Capsule (K antigen), flagella (H antigen), pili (fimbriae)
- Causes enteric fever
- Salmonella
- colonies isolated from a vet student show motile rods with H2S, non fermenter of lactose. suspect?
- salmonella enteritidis
- ADP ribosylates Gs, adenylate cyclase is over-active in the small intestine
- Vibrio cholerae
- Photographer from National Geographic in Thailand presents with fever, cramps, hemorrhagic mucosa, & diarrhea. Culture reveals bug that is Lac -, doesnÂ’t make H2S, isnÂ’t motile
- Shigella dysenteria
- Mechanism by which shigella causes cell damage:
- cleaves rRNA w/ inhibition of 60S protein synthesis
- produces hemorrhagic mucosa in the distal colon
- Shigella dysenteriae