lungs 4
Terms
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- Bronchiectasis definition
- permanent dilation of bronchi, w/ peri-bronchial inflam & organization w/ muco-purulent debris
- Bronchiectasis path
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- Impaired mucus flow -> microbial colonization -> microbial products (elastase)
– all of this causes mucus hypersecretion and structural damage - Bronchiectasis Sx
- cough, purulent sputum, hemoptysis, localized rales or rhonchi, and clubbing
- Bronchiectasis causes of impaired flow how?
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1) Obstruction to outflow
2) Abnormal mucus (CF)
3) abnormal ciliary function (1oCD) - Bronchiectasis treatment
- drainage, antibiotics, and bronchodilators – surgical resection is rarely needed
- Bronchiectasis radiology
- airway dilation which extends to the periphery
- Upper>lower lobe emphysema
- suggests centrilobular type, from smoking
- Lower>upper lobe emphysema
- suggests panlobular type, from A1AT deficiency
- BOOP definition
- Bronchiolar lumen and alveolar airspace fibroblastic proliferation
- BOOP clinical
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- acute onset cough, dyspnea, fever, and malaise
- multiple associations (collagen-vascular disease)
- most patients respond to corticosteroids - BOOP radiology
- will show multiple patchy airspace infiltrates
- BOOP path
- will show patchy fibromyxoid plugs in distal bronchioles and alveoli, +/- endogenous lipid pneumonia