Pathology Sepsis
Terms
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- Sepsis definition
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systemic inflammation
coagulopathy
low bp - term for positive blood culture
- bacteremia
- term for sepsis plus hypoxemia or elevated plasma lactate levels or oliguria
- sepsis sndrome
- term for sepsis plus hypotension despite adequate volume
- septic shock
- 6 examples of microbial products that initiate innate immune response
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bacterial endo toxin LPS
lipoteichoic acid LTA
peptidoglycan
bacterial exotoxins
double stranded RNA
malaria pigment - response to recognition of microbial products in blood stream
- systemic inflammatory response
- 3 pro inflammatory cytokines and effects
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TNF alpha
IL 1
IL 6
Induce fever
upregulate acute phase response by producing complement, C-reactive protein, procalcitonin, other acute phase proteins - upregulated enzymes that are part of the innate immune rsponse : 2 eg's
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COX-2
Inducible nitric oxide - 3 results of activiation oin sepsis
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microvascular thrombosis
tissue ishemia
multiorgan failure - 3 eg's counterinflammatory mediateors released in response to SIRS
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IL 6
IL 10
TGF beta - Treatment of sepsis
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antimicrobial therapy
Protein C anticoagulant pathway is impaired--activated protein C has been used