Experimental Methods
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- Selection of method to employ depends upon: (3)
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1. WHAT measuring
2. HOW measures
3. WHEN & WHY to use the measure - Types of Invasive Measures: (3)
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1. Single/Multi Unit Recording
2. Lesions
3. Genetic Manipulation - When to use invasive measures
- requirement of DIRECT access or change to the brain
- Types of Lesion Methods: (3)
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1. Temporary
2. Permanent - Types of Genetic Manipulation (3)
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1. Knock-down: less active gene
2. Knock-in: mutation
3. Knock-out: gene taken out (ability to produce protein removed by alteration/replacement of dummy code) - NonInvasive Structural Methods are...what are they? (2)
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Volumetry Analysis.
1. CT: visualize fractures and leakage, no wh/gr matter diff
2. MRI: exploit NMR and RF. - (2) types of MRI
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1. T1: White matter BRIGHT, view anatomical structures (familliar brain)
2. T2: Grey matter BRIGHT, view tumors, swelling. - (2) Types of non Invasive Functional Methods
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1: Direct: measure n. firing
2. Indirect: measure blood flow - (2) Types Direct methods
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1: EEG- changes in extracellular current, EPSP&IPSP (ERP)
2: MEG- Magnetic field arising from e curent as result of stimulus - ERP
- Event-related Potentials: AVGing of time-locked segments of EEG to stimulus
- (2) Types of Indirect Methods
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1. PET- inject of isotopes of glucose or other relevant chemical
2. fMRI- measure areas of blood overcompensation - EEG freq oscillations indicate..
- different processes.