FA bros - neur
Terms
undefined, object
copy deck
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Microglia
1) what kind of cell?
2) what layer does it originate from?
3) Response to tissue damage? -
Microglia
1) CNS phagocyte
2) Mesoderm origin
3) transform into large ameboid phagocytic cells in response to tissue damage -
Astrocyte
1) where is it found
2) fxn?
3) marker? -
Astrocyte
1) CNS
2) physical support, repair, K metabolism, help maintain blood-brain barrier
3) marker: GFAP -
Ependymal cells
1) where is it found?
2) fxn? -
Ependymal cells
1) CNS
2) inner lining of ventricles -
Oligodendrocyte
1) where is it found?
2) fxn?
3) what stain do you use and what does it look like?
4) Predominant in white or gray matter? -
Oligodendrocytes
1) CNS
2) myelinate CNS axons
3) Nissl stain - look like small nuclei with dark chromatin and little cytoplasm
4) white matter - what cells fuse to form multinucleated giant cells in CNS when infected by HIV
- microglia
- what cells are destroyed in Multiple Sclerosis
- Oligodendrocytes
-
Schwann cells
1) where are they found
2) what layer are they formed from
3) fxn -
Schwann Cells
1) PNS
2) ectoderm
3) myelinate only 1 PNS axon and promote axonal regeneration - what is an example of schwannoma and what CN are involved
-
acoustic neuroma
CN VII, VIII - what are the peripheral nerve layers?
-
peripheral nerve layers:
endoneurium - around single nerve fiber
perineurium - permeability barrier
epineurium - surrounds the entire nerve -
Meissner's corpuscles
1) where found
2) fxn? -
Meissner's
1) small encapsulated nerve endings found in DERMIS OF PALMS, SOLES, DIGITS OF SKIN
2) LIGHT DISCRIMINATORY TOUCH OF GLABROUS (HAIRLESS) SKIN -
Merkel's corpuscle
1) where
2) fxn -
Merkel's
1) cup shaped nerve endings in DERMIS OF FINGERTIPS, HAIR FOLLICLES, HARD PALATE
2) light, crude touch -
Inner ear
bony labyrinth is made up of?
what is it filled with? -
Bony labyrinth
cochlea, vestibule, semicircular canals
perilymph - Na rich -
Inner ear
membranous labyrinth is made up of?
what is it filled with? -
cochlear duct, utricle, saccule, semicircular canals
endolymph - K rich -
Inner ear
hair cell fxn -
hair cells
spatial orientation - vestibule
hearing - cochlea -
inner ear
where is high frequency sound picked up -
high frequency sound is picked up in...
base of cochlea -
inner ear
where is low frequency sound picked up -
low frequency sound is picked up in.....
apex of cochlea -
inner ear - maculae
1) where?
2) fxn? -
maculae
1) utricle/saccule
2) detect linear accelaration -
inner ear - ampullae
1) where?
2) fxn? -
ampullae
1) semicircular canal
2) detect Angular Acceleration - hearing loss in eldery goes from?
- high --> low frequency
-
blood brain barrier
1) formed by?
2) what crosses readily?
3) how do glucose and aa cross
4) where in the brain is there no BBB -
BBB
formed by: ENDOTHELIAL CELLS TIGHT JXN, BASEMENT MEMBRANE, ASTROCYTE PROCESSES
2) nonpolar/lipid soluble substances cross readily
3) glucose/aa cross by carrier mediated transport
4) area postrema (vomit after chemo), neurohypophysis (ADH release) - hypothalamus fxn
-
Hypothalamas wears TAN HATS
Thirst/Water balance (supraoptic nucleus)
Adenohypophysis control - releasing factors
Neurohypophysis - releases hormones synthesized in hypothalamic nuclei
Hunger (anorexia/starvation destroys lateral nucleus)
Autonomic regulation (anterior hypothal regulates parasympathetic; posterior hypothal regulates sympathetic)
Temp regulation (post regulates heat conservation and production when cold; ant coordinates cooling when hot) A/C=ANT/COOLING ; POST POIKILOTHERM
Sexual urges and emotions - Septal nucleus - destruction-> rage) -
Post pit
1) receives projections from?
2) secretes? -
1)supraoptic (ADH)
2) paraventricular (oxytocin) -
Thalamus
1) receive info from? -
1) ascending sensory info
Lat geniculate nucleus - visual (LAT FOR LIGHT)
Med geniculate nucleus - auditory (MEDIAL FOR MUSIC)
VPL - body sensation
VPM - facial sensation (CN V)
VA/VL - motor - limbic system fxn?
-
5 F's
feeding
fighting
feeling
flight
sex -
Basal ganglia
1) fxn
2) decreased input from the substantia nigra results in? -
1) voluntary movements and making postural adjustments
2) parkinson's disease - like symptoms - frontal lobe fxn
-
"Executive fxns"
planning, inhibition, concentration, orientation, language, abstraction, judgment, motor regulation, mood, social judgement - Brodmann's premotor area
- 6
- Brodmann's primary motor area
- 4
- Brodmann's primary sensory areas
- 3,1,2
-
Brodmann's motor speech area?
what is this area called? -
44, 45
Broca's area - Brodmann's primary auditory cortex area?
- 41, 42
-
Brodmann's associative auditory cortex area?
what is this area called? -
22
Wernicke's - Bordmann's primary visual cortex area
- 17
- Brodmann's frontal eye fields area
- 8
-
what supplies medial surface of the brain?
what area of the brain is this? -
anterior cerebral artery
leg-foot area of motor and sensory cortex -
what supplies the lateral aspect of the brain?
what areas are affected? -
middle cerebral artery
trunk-arm-face area of motor/sensory cortex
Broca's area
Wernicke's area -
where is the most common circle of Willis aneurysm?
what kind of defects would it cause -
anterior communicating artery
visual field defects -
where is the most common area of aneurysm?
what kind of defects would it cause -
posterior communicating artery
CN III palsy -
what division of the middle cerebral artery is called the "arteries of stroke"?
what areas are affected? -
lateral striate artery
internal capsule, caudate, putamen, globus pallidus - if you have a stroke in the anterior circle, what symptomatology do you get?
- general sensory/motor dysfxn, aphasia
- if you have a stroke in the posterior circle, what kind of symptomatology do you get?
-
CN deficits (vertigo, visual deficit)
coma
cerebellar deficits (ataxia - where are venous sinuses located?
- run in dura mater where meningeal and periosteal layers separate
- blood supply of veins?
- cerebral vein --> venous sinuses --> internal jugular vein
- what connects the lateral ventricle to the 3rd ventricle
- foramen of Monro
- what connects the 3rd and 4th ventricle
- aqueduct of Sylvius
- what connects the 4th ventricle to the subarachnoid space
-
Foramina of Luschka (lateral)
Foramina of Magendie (medial) - where does vertebral disk herniation usu occur
- btw L5, S1
- at what level do you go to get a CSF sample from the lumbars?
-
L3/L4
L4/L5 - at what level does the spinal cord end?
- L1/L2
- at what level does the subarachnoid space end
- S2
- what structure do you not pierce through when doing lumbar punctures
- pia
- cuneate fasciculus affects what part of body
-
upper body, extremities
pressure, vibration, touch, proprioception - gracilis fasciculus affects what part of the body
-
lower body, extremities
pressure, vibration, touch, proprioception - lateral corticospinal tract is responsible for what
- voluntary motor movements
- spinothalamic tract is responsible for what
- pain and temperature
- what 2 fascicles make up the dorsal column
-
cuneate - arms
gracilis - legs